The Role of Regulatory T Cells in Cancer Treatment Resistance

Despite tremendous progress in cancer treatment in recent years, treatment resistance is still a major challenge for a great number of patients. One of the main causes is regulatory T lymphocytes (Tregs), which suppress excessive inflammatory responses via the secretion of immunosuppressive cytokine...

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Published inInternational journal of molecular sciences Vol. 24; no. 18; p. 14114
Main Authors Dąbrowska, Anna, Grubba, Magdalena, Balihodzic, Amar, Szot, Olga, Sobocki, Bartosz Kamil, Perdyan, Adrian
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 01.09.2023
MDPI
Subjects
Antigens
Biomarkers
Cancer
Cancer therapies
Chemotherapy
Cytokines
Drug resistance
Health aspects
Homeostasis
Immunotherapy
Ipilimumab
Lung cancer
Lymphocytes
Medical research
Melanoma
Proteins
Radiation therapy
radiotherapy
regulatory T cell
resistance mechanisms
Review
T cells
Tumors
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Summary:Despite tremendous progress in cancer treatment in recent years, treatment resistance is still a major challenge for a great number of patients. One of the main causes is regulatory T lymphocytes (Tregs), which suppress excessive inflammatory responses via the secretion of immunosuppressive cytokines and upregulate the immune checkpoints. Their abundance causes an immunosuppressive reprogramming of the tumor environment, which is ideal for tumor growth and drug inefficiency. Hence, regiments that can regain tumor immunogenicity are a promising strategy to overcome Tregs-mediated drug resistance. However, to develop effective therapeutic regimens, it is essential to understand the molecular mechanisms of Treg-mediated resistance. In this article, we gathered a comprehensive summary of the current knowledge on molecular mechanisms and the role of Tregs in cancer treatment resistance, including cancer immunotherapy, targeted therapy, chemotherapy, and radiotherapy.
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These authors contributed equally to this work.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms241814114