Genetic polymorphism of NOS3 with susceptibility to deep vein thrombosis after orthopedic surgery: a case-control study in Chinese Han population

• Published in: PloS one Vol. 8; no. 7; p. e70033
• Main Authors: Qin, Jizheng, Dai, Jin, Xu, Zhihong, Chen, Dongyang, Qin, Jianghui, Shi, Dongquan, Teng, Huajian, Jiang, Qing
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 26.07.2013; Public Library of Science (PLoS)
• Subjects: Aged; Aging; Alleles; Asian Continental Ancestry Group - genetics; Biology; Blood pressure; Bone surgery; Cardiovascular disease; Cardiovascular diseases; Case-Control Studies; China; Complications; Coronary vessels; Endothelial cells; Endothelium; Female; Gene frequency; Gene polymorphism; Genetic factors; Genotype; Heart diseases; Homeostasis; Hospitals; Humans; Hypertension; Joint surgery; Male; Medical diagnosis; Medical schools; Medicine; Middle Aged; Nitric oxide; Nitric Oxide Synthase Type III - genetics; Nitric-oxide synthase; NOS3 protein; Orthopedic Procedures - adverse effects; Orthopedics; Pathogenesis; Polymorphism; Polymorphism, Single Nucleotide; Population; Population studies; Rodents; Smooth muscle; Studies; Surgery; Thromboembolism; Thrombosis; Venous Thrombosis - etiology; Venous Thrombosis - genetics; China

Deep vein thrombosis is one of the common complications of orthopedic surgery. Studies indicated that genetic factors played a considerable role in the pathogenesis of deep vein thrombosis. Endothelial nitric oxide synthase which encoded by nitric oxide synthase 3 (NOS3), can generate nitric oxide i...