Genetic polymorphism of NOS3 with susceptibility to deep vein thrombosis after orthopedic surgery: a case-control study in Chinese Han population

• Published in: PloS one Vol. 8; no. 7; p. e70033
• Main Authors: Qin, Jizheng, Dai, Jin, Xu, Zhihong, Chen, Dongyang, Qin, Jianghui, Shi, Dongquan, Teng, Huajian, Jiang, Qing
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 26.07.2013; Public Library of Science (PLoS)
• Subjects: Aged; Aging; Alleles; Asian Continental Ancestry Group - genetics; Biology; Blood pressure; Bone surgery; Cardiovascular disease; Cardiovascular diseases; Case-Control Studies; China; Complications; Coronary vessels; Endothelial cells; Endothelium; Female; Gene frequency; Gene polymorphism; Genetic factors; Genotype; Heart diseases; Homeostasis; Hospitals; Humans; Hypertension; Joint surgery; Male; Medical diagnosis; Medical schools; Medicine; Middle Aged; Nitric oxide; Nitric Oxide Synthase Type III - genetics; Nitric-oxide synthase; NOS3 protein; Orthopedic Procedures - adverse effects; Orthopedics; Pathogenesis; Polymorphism; Polymorphism, Single Nucleotide; Population; Population studies; Rodents; Smooth muscle; Studies; Surgery; Thromboembolism; Thrombosis; Venous Thrombosis - etiology; Venous Thrombosis - genetics; China
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0070033

Deep vein thrombosis is one of the common complications of orthopedic surgery. Studies indicated that genetic factors played a considerable role in the pathogenesis of deep vein thrombosis. Endothelial nitric oxide synthase which encoded by nitric oxide synthase 3 (NOS3), can generate nitric oxide in endothelial cells. As a predominant regulator for vascular homeostasis, nitric oxide might be involved in the pathogenesis of thrombosis. It had been proved that the NOS3 polymorphism (rs1799983) was associated with the development of cardiovascular diseases. Our objective was to evaluate the association between the NOS3 polymorphism (rs1799983) and deep vein thrombosis after orthopedic surgery in Chinese Han population. The polymorphism was genotyped in 224 subjects with deep vein thrombosis after orthopedic surgery and 580 controls. Allele and genotype frequencies were compared between subjects with deep vein thrombosis and control subjects. The allele and genotype frequencies of the NOS3 polymorphism (rs1799983) were significantly different between subjects with deep vein thrombosis and control subjects. There were also significant differences when the subjects were stratified by gender, surgery type and hypertension status. These findings suggested that the NOS3 polymorphism (rs1799983) was associated with susceptibility to the deep vein thrombosis after orthopedic surgery in Chinese Han population, and NOS3 might play a role in the development of deep vein thrombosis after orthopedic surgery.