Genetic polymorphism of NOS3 with susceptibility to deep vein thrombosis after orthopedic surgery: a case-control study in Chinese Han population

Deep vein thrombosis is one of the common complications of orthopedic surgery. Studies indicated that genetic factors played a considerable role in the pathogenesis of deep vein thrombosis. Endothelial nitric oxide synthase which encoded by nitric oxide synthase 3 (NOS3), can generate nitric oxide i...

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Published inPloS one Vol. 8; no. 7; p. e70033
Main Authors Qin, Jizheng, Dai, Jin, Xu, Zhihong, Chen, Dongyang, Qin, Jianghui, Shi, Dongquan, Teng, Huajian, Jiang, Qing
Format Journal Article
LanguageEnglish
Published United States Public Library of Science 26.07.2013
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Abstract Deep vein thrombosis is one of the common complications of orthopedic surgery. Studies indicated that genetic factors played a considerable role in the pathogenesis of deep vein thrombosis. Endothelial nitric oxide synthase which encoded by nitric oxide synthase 3 (NOS3), can generate nitric oxide in endothelial cells. As a predominant regulator for vascular homeostasis, nitric oxide might be involved in the pathogenesis of thrombosis. It had been proved that the NOS3 polymorphism (rs1799983) was associated with the development of cardiovascular diseases. Our objective was to evaluate the association between the NOS3 polymorphism (rs1799983) and deep vein thrombosis after orthopedic surgery in Chinese Han population. The polymorphism was genotyped in 224 subjects with deep vein thrombosis after orthopedic surgery and 580 controls. Allele and genotype frequencies were compared between subjects with deep vein thrombosis and control subjects. The allele and genotype frequencies of the NOS3 polymorphism (rs1799983) were significantly different between subjects with deep vein thrombosis and control subjects. There were also significant differences when the subjects were stratified by gender, surgery type and hypertension status. These findings suggested that the NOS3 polymorphism (rs1799983) was associated with susceptibility to the deep vein thrombosis after orthopedic surgery in Chinese Han population, and NOS3 might play a role in the development of deep vein thrombosis after orthopedic surgery.
AbstractList Deep vein thrombosis is one of the common complications of orthopedic surgery. Studies indicated that genetic factors played a considerable role in the pathogenesis of deep vein thrombosis. Endothelial nitric oxide synthase which encoded by nitric oxide synthase 3 (NOS3), can generate nitric oxide in endothelial cells. As a predominant regulator for vascular homeostasis, nitric oxide might be involved in the pathogenesis of thrombosis. It had been proved that the NOS3 polymorphism (rs1799983) was associated with the development of cardiovascular diseases. Our objective was to evaluate the association between the NOS3 polymorphism (rs1799983) and deep vein thrombosis after orthopedic surgery in Chinese Han population. The polymorphism was genotyped in 224 subjects with deep vein thrombosis after orthopedic surgery and 580 controls. Allele and genotype frequencies were compared between subjects with deep vein thrombosis and control subjects. The allele and genotype frequencies of the NOS3 polymorphism (rs1799983) were significantly different between subjects with deep vein thrombosis and control subjects. There were also significant differences when the subjects were stratified by gender, surgery type and hypertension status. These findings suggested that the NOS3 polymorphism (rs1799983) was associated with susceptibility to the deep vein thrombosis after orthopedic surgery in Chinese Han population, and NOS3 might play a role in the development of deep vein thrombosis after orthopedic surgery.
Author Xu, Zhihong
Qin, Jianghui
Shi, Dongquan
Jiang, Qing
Dai, Jin
Qin, Jizheng
Chen, Dongyang
Teng, Huajian
AuthorAffiliation Yale School of Public Health, United States of America
1 The Center of Diagnosis and Treatment for Joint Disease, Drum Tower Hospital Affiliated to Medical School of Nanjing University, Jiangsu, PR China
2 Joint Research Center for Bone and Joint Disease, Model Animal Research Center (MARC), Nanjing University, Jiangsu, PR China
AuthorAffiliation_xml – name: 1 The Center of Diagnosis and Treatment for Joint Disease, Drum Tower Hospital Affiliated to Medical School of Nanjing University, Jiangsu, PR China
– name: Yale School of Public Health, United States of America
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Competing Interests: The authors have declared that no competing interests exist.
Conceived and designed the experiments: DS QJ. Performed the experiments: JzQ JD. Analyzed the data: JzQ JD ZX DC JhQ. Contributed reagents/materials/analysis tools: ZX DC JhQ HT DS. Wrote the paper: JzQ JD DS QJ. Revised the manuscript: ZX DC HT JhQ.
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Snippet Deep vein thrombosis is one of the common complications of orthopedic surgery. Studies indicated that genetic factors played a considerable role in the...
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SubjectTerms Aged
Aging
Alleles
Asian Continental Ancestry Group - genetics
Biology
Blood pressure
Bone surgery
Cardiovascular disease
Cardiovascular diseases
Case-Control Studies
China
Complications
Coronary vessels
Endothelial cells
Endothelium
Female
Gene frequency
Gene polymorphism
Genetic factors
Genotype
Heart diseases
Homeostasis
Hospitals
Humans
Hypertension
Joint surgery
Male
Medical diagnosis
Medical schools
Medicine
Middle Aged
Nitric oxide
Nitric Oxide Synthase Type III - genetics
Nitric-oxide synthase
NOS3 protein
Orthopedic Procedures - adverse effects
Orthopedics
Pathogenesis
Polymorphism
Polymorphism, Single Nucleotide
Population
Population studies
Rodents
Smooth muscle
Studies
Surgery
Thromboembolism
Thrombosis
Venous Thrombosis - etiology
Venous Thrombosis - genetics
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Title Genetic polymorphism of NOS3 with susceptibility to deep vein thrombosis after orthopedic surgery: a case-control study in Chinese Han population
URI https://www.ncbi.nlm.nih.gov/pubmed/23922896
https://www.proquest.com/docview/1440993863
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https://doaj.org/article/10007af6bebd4665968fd6b2d2420457
http://dx.doi.org/10.1371/journal.pone.0070033
Volume 8
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