Genetic polymorphism of NOS3 with susceptibility to deep vein thrombosis after orthopedic surgery: a case-control study in Chinese Han population
Deep vein thrombosis is one of the common complications of orthopedic surgery. Studies indicated that genetic factors played a considerable role in the pathogenesis of deep vein thrombosis. Endothelial nitric oxide synthase which encoded by nitric oxide synthase 3 (NOS3), can generate nitric oxide i...
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Published in | PloS one Vol. 8; no. 7; p. e70033 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
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Public Library of Science
26.07.2013
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Abstract | Deep vein thrombosis is one of the common complications of orthopedic surgery. Studies indicated that genetic factors played a considerable role in the pathogenesis of deep vein thrombosis. Endothelial nitric oxide synthase which encoded by nitric oxide synthase 3 (NOS3), can generate nitric oxide in endothelial cells. As a predominant regulator for vascular homeostasis, nitric oxide might be involved in the pathogenesis of thrombosis. It had been proved that the NOS3 polymorphism (rs1799983) was associated with the development of cardiovascular diseases. Our objective was to evaluate the association between the NOS3 polymorphism (rs1799983) and deep vein thrombosis after orthopedic surgery in Chinese Han population. The polymorphism was genotyped in 224 subjects with deep vein thrombosis after orthopedic surgery and 580 controls. Allele and genotype frequencies were compared between subjects with deep vein thrombosis and control subjects. The allele and genotype frequencies of the NOS3 polymorphism (rs1799983) were significantly different between subjects with deep vein thrombosis and control subjects. There were also significant differences when the subjects were stratified by gender, surgery type and hypertension status. These findings suggested that the NOS3 polymorphism (rs1799983) was associated with susceptibility to the deep vein thrombosis after orthopedic surgery in Chinese Han population, and NOS3 might play a role in the development of deep vein thrombosis after orthopedic surgery. |
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AbstractList | Deep vein thrombosis is one of the common complications of orthopedic surgery. Studies indicated that genetic factors played a considerable role in the pathogenesis of deep vein thrombosis. Endothelial nitric oxide synthase which encoded by nitric oxide synthase 3 (NOS3), can generate nitric oxide in endothelial cells. As a predominant regulator for vascular homeostasis, nitric oxide might be involved in the pathogenesis of thrombosis. It had been proved that the NOS3 polymorphism (rs1799983) was associated with the development of cardiovascular diseases. Our objective was to evaluate the association between the NOS3 polymorphism (rs1799983) and deep vein thrombosis after orthopedic surgery in Chinese Han population. The polymorphism was genotyped in 224 subjects with deep vein thrombosis after orthopedic surgery and 580 controls. Allele and genotype frequencies were compared between subjects with deep vein thrombosis and control subjects. The allele and genotype frequencies of the NOS3 polymorphism (rs1799983) were significantly different between subjects with deep vein thrombosis and control subjects. There were also significant differences when the subjects were stratified by gender, surgery type and hypertension status. These findings suggested that the NOS3 polymorphism (rs1799983) was associated with susceptibility to the deep vein thrombosis after orthopedic surgery in Chinese Han population, and NOS3 might play a role in the development of deep vein thrombosis after orthopedic surgery. |
Author | Xu, Zhihong Qin, Jianghui Shi, Dongquan Jiang, Qing Dai, Jin Qin, Jizheng Chen, Dongyang Teng, Huajian |
AuthorAffiliation | Yale School of Public Health, United States of America 1 The Center of Diagnosis and Treatment for Joint Disease, Drum Tower Hospital Affiliated to Medical School of Nanjing University, Jiangsu, PR China 2 Joint Research Center for Bone and Joint Disease, Model Animal Research Center (MARC), Nanjing University, Jiangsu, PR China |
AuthorAffiliation_xml | – name: 1 The Center of Diagnosis and Treatment for Joint Disease, Drum Tower Hospital Affiliated to Medical School of Nanjing University, Jiangsu, PR China – name: Yale School of Public Health, United States of America – name: 2 Joint Research Center for Bone and Joint Disease, Model Animal Research Center (MARC), Nanjing University, Jiangsu, PR China |
Author_xml | – sequence: 1 givenname: Jizheng surname: Qin fullname: Qin, Jizheng organization: The Center of Diagnosis and Treatment for Joint Disease, Drum Tower Hospital Affiliated to Medical School of Nanjing University, Jiangsu, PR China – sequence: 2 givenname: Jin surname: Dai fullname: Dai, Jin – sequence: 3 givenname: Zhihong surname: Xu fullname: Xu, Zhihong – sequence: 4 givenname: Dongyang surname: Chen fullname: Chen, Dongyang – sequence: 5 givenname: Jianghui surname: Qin fullname: Qin, Jianghui – sequence: 6 givenname: Dongquan surname: Shi fullname: Shi, Dongquan – sequence: 7 givenname: Huajian surname: Teng fullname: Teng, Huajian – sequence: 8 givenname: Qing surname: Jiang fullname: Jiang, Qing |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/23922896$$D View this record in MEDLINE/PubMed |
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CitedBy_id | crossref_primary_10_1186_s12864_018_4433_3 crossref_primary_10_5114_amsad_2019_84539 crossref_primary_10_2106_JBJS_RVW_20_00240 crossref_primary_10_5551_jat_56333 crossref_primary_10_1002_jcp_29436 crossref_primary_10_1016_j_phymed_2022_153967 crossref_primary_10_1007_s00394_016_1203_3 crossref_primary_10_1177_02683555211016626 |
Cites_doi | 10.1053/euhj.2002.3400 10.1161/01.HYP.16.2.170 10.1038/333664a0 10.1161/01.HYP.29.3.736 10.1016/S0049-3848(00)00288-7 10.1161/01.CIR.88.1.77 10.1016/j.thromres.2010.11.034 10.1007/s00418-004-0675-z 10.1378/chest.141.4.1129b 10.1182/blood-2008-11-190389 10.1111/j.1538-7836.2004.00701.x 10.1073/pnas.97.6.2832 10.1056/NEJM199007053230105 10.1161/01.HYP.25.2.194 10.1172/JCI40782 10.1038/sj.jhh.1001801 10.1016/j.jacc.2005.05.072 10.1111/j.1476-5381.1987.tb11367.x 10.1161/01.CIR.91.7.1981 |
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Copyright | 2013 Qin et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2013 Qin et al 2013 Qin et al |
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Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Competing Interests: The authors have declared that no competing interests exist. Conceived and designed the experiments: DS QJ. Performed the experiments: JzQ JD. Analyzed the data: JzQ JD ZX DC JhQ. Contributed reagents/materials/analysis tools: ZX DC JhQ HT DS. Wrote the paper: JzQ JD DS QJ. Revised the manuscript: ZX DC HT JhQ. |
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Snippet | Deep vein thrombosis is one of the common complications of orthopedic surgery. Studies indicated that genetic factors played a considerable role in the... |
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SubjectTerms | Aged Aging Alleles Asian Continental Ancestry Group - genetics Biology Blood pressure Bone surgery Cardiovascular disease Cardiovascular diseases Case-Control Studies China Complications Coronary vessels Endothelial cells Endothelium Female Gene frequency Gene polymorphism Genetic factors Genotype Heart diseases Homeostasis Hospitals Humans Hypertension Joint surgery Male Medical diagnosis Medical schools Medicine Middle Aged Nitric oxide Nitric Oxide Synthase Type III - genetics Nitric-oxide synthase NOS3 protein Orthopedic Procedures - adverse effects Orthopedics Pathogenesis Polymorphism Polymorphism, Single Nucleotide Population Population studies Rodents Smooth muscle Studies Surgery Thromboembolism Thrombosis Venous Thrombosis - etiology Venous Thrombosis - genetics |
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Title | Genetic polymorphism of NOS3 with susceptibility to deep vein thrombosis after orthopedic surgery: a case-control study in Chinese Han population |
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