Intracerebroventricular injection of adiponectin regulates locomotor activity in rats

Enhancing exercise motivation is the best way to prevent obesity and diabetes. In this study, we examined whether adiponectin affects locomotion activity in Wister and Spontaneously-Running Tokushima-Shikoku (SPORTS) rats using two types of behavioral assays: home cage and wheel running activity. SP...

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Bibliographic Details
Published inThe Journal of Medical Investigation Vol. 62; no. 3.4; pp. 199 - 203
Main Authors Miyatake, Yumiko, Shiuchi, Tetsuya, Ueta, Tomoyo, Taniguchi, Yasuko, Futami, Akari, Sato, Fukiko, Kitamura, Tadahiro, Tsutsumi, Rie, Harada, Nagakatsu, Nakaya, Yutaka, Sakaue, Hiroshi
Format Journal Article
LanguageEnglish
Published Japan The University of Tokushima Faculty of Medicine 2015
Subjects
Adiponectin
Adiponectin - administration & dosage
Adiponectin - pharmacology
Animals
brain
Hypothalamus - drug effects
Hypothalamus - physiology
Injections, Intraventricular
Male
Motor Activity - drug effects
Rats
Rats, Wistar
Sodium Glutamate - pharmacology
spontaneous activity
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Summary:Enhancing exercise motivation is the best way to prevent obesity and diabetes. In this study, we examined whether adiponectin affects locomotion activity in Wister and Spontaneously-Running Tokushima-Shikoku (SPORTS) rats using two types of behavioral assays: home cage and wheel running activity. SPORTS rats were established from an original line from Wister strain that had shown high level of wheel running activity in our laboratory. Injection of adiponectin into the lateral ventricle of Wister rats and SPORTS rats decreased home cage activity, but no change was observed in the food intake and oxygen consumption. This result indicates the possibility that adiponectin can reduce non-exercise activity thermogenesis (NEAT) and physical activity via the central nervous system. In contrast, injection of adiponectin did not change wheel running activity in SPORTS rats. We produced hypothalamus-destructed model rat using monosodium glutamate (MSG) to elucidate the regulation site of adiponectin. Injection of adiponectin into MSG-treated SPORTS rats did not change amount of home cage activity and food intake, suggesting that adiponectin action on home cage activity was in the hypothalamic area. These results suggest that adiponectin regulates locomotion activity through mediobasal hypothalamus. J. Med. Invest. 62: 199-203, August, 2015
ISSN:1343-1420
1349-6867
DOI:10.2152/jmi.62.199