Human papillomavirus (HPV) prevalence and associated risk factors in women from Curaçao

• Published in: PloS one Vol. 13; no. 7; p. e0199624
• Main Authors: Hooi, Desiree J, Lissenberg-Witte, Birgit I, Kenter, Gemma, de Koning, Maurits N C, Gomes Bravio, Igor, Ardts, Kim, Kleinmoedig, Suhaina, Benita, Edlyn, Pinedo, Herbert M, Berkhof, Johannes, Quint, Wim G V, Meijer, Chris J L M
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 13.07.2018; Public Library of Science (PLoS)
• Subjects: Adult; Age; Aged; Biology and life sciences; Biopsy; Cancer; Cellular biology; Cervical cancer; Cervix; Curacao - epidemiology; Cytology; Earth Sciences; Epidemiology; Female; Genotype; Genotype & phenotype; Genotypes; Human papillomavirus; Humans; Internet; Laboratories; Medicine and Health Sciences; Middle Aged; Papillomaviridae - genetics; Papillomavirus Infections - epidemiology; Papillomavirus Infections - virology; Pathology; People and places; Population; Prevalence; Public Health Surveillance; Registries; Research and Analysis Methods; Risk analysis; Risk Factors; Sexual Behavior; Surveys and Questionnaires; Systematic review; Vaccination; Vaccines; Womens health; World population; Curacao; Netherlands
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0199624

In the Caribbean region, a notable difference in HPV-prevalence and genotypes distribution between the islands is observed. Recently we found in Curaçao a low incidence of HPV16 and 18 in cervical cancer compared to the standard world population. We aimed to determine HPV-prevalence, HPV-genotype distribution and associated risk-factors in women from Curaçao. 5000 women aged 25-65 years were randomly selected from the national Population Register. HPV was detected by means of GP5+/6+PCR EIA and GP 5+/6+amplimers from HPV-positive samples were genotyped with a reverse hybridisation assay. We also collected personal data and data on risk-factors. 1075 women were enrolled in the study. Overall HPV-prevalence was 19.7%. Most frequent genotypes were HPV16 (2.3%), 35 (2.1%) and 52 (1.8%). Twenty-seven women detected with abnormal cytology (i.e.≥ASC-US) were referred for biopsy. In women with normal cytology (n = 1048), HPV-prevalence was 17.9% and the most common high-risk HPV (hrHPV)-types were HPV35 (2.0%), 18 (1.8%), 16 (1.5%) and 52 (1.5%). The highest HPV-prevalence (32.8%) was found in the age-group: 25-34 (n = 247). HPV positive women started sex at a younger age (p = 0.032). HPV-prevalence in the overall population is high and HPV16 was the most common genotype followed by 35 and 18. In women with normal cytology HPV35 is the most common genotype followed by HPV18, 52 and 16. The high HPV-prevalence (32.8%) in women of 25-34 years argue for introduction of cervical cancer prevention strategies. HPV-type distribution found in Curaçao should be taken into account when considering the choice for prophylactic vaccination.