De novo Acute Myelogenous Leukemia with Trilineage Myelodysplasia Associated with t(8;21)(q22;q22)

• Published in: Internal Medicine Vol. 38; no. 7; pp. 607 - 611
• Main Authors: FUJISAWA, Shin, TOGAWA, Jun-ichi, TANAKA, Masatsugu, KOHARAZAWA, Hideyuki, AOBA, Mami, FUJITA, Hiroyuki, MURATA, Takashi, KANAMORI, Heiwa, MATSUZAKI, Michio, MOHRI, Hiroshi, ISHIGATSUBO, Yoshiaki
• Format: Journal Article
• Language: English
• Published: Tokyo The Japanese Society of Internal Medicine 1999; Japanese Society of Internal Medicine
• Subjects: Antineoplastic Combined Chemotherapy Protocols - administration & dosage; Biological and medical sciences; chromosomal abnormality; Chromosomes, Human, Pair 21 - genetics; Chromosomes, Human, Pair 8 - genetics; Cytarabine - administration & dosage; Daunorubicin - administration & dosage; Hematologic and hematopoietic diseases; Humans; Karyotyping; Leukemia, Myeloid, Acute - complications; Leukemia, Myeloid, Acute - drug therapy; Leukemia, Myeloid, Acute - genetics; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis; leukemogenesis; Male; Medical sciences; Middle Aged; myelodysplastic change; Myelodysplastic Syndromes - complications; Myelodysplastic Syndromes - drug therapy; Myelodysplastic Syndromes - genetics; Prednisolone - administration & dosage; Translocation, Genetic; Human; Pathogenesis; Acute; Reverse transcription; Male; Malignant hemopathy; De novo; Myelodysplastic syndrome; Case study; Polymerase chain reaction; Adult; Molecular biology; Acute myelocytic leukemia
• ISSN: 0918-2918; 1349-7235
• DOI: 10.2169/internalmedicine.38.607

We describe a rare case of de novo acute myelogenous leukemia with trilineage myelodysplasia (AML/TMDS) associated with t(8;21)(q22;q22). The patient was admitted to our hospital with leukocytopenia. AML/TMDS was diagnosed by excess myeloblasts and morphological findings of bone marrow. The karyotype revealed 45, X, -Y, t(8;21)(q22;q22) in 17 of 20 analyzed mitoses, and also AML1/MTG8 transcripts were detected by the reverse transcription polymerase chain reaction (RT-PCR) method. The patient achieved a complete remission with a combination chemotherapy of daunorubicin, cytarabine, and prednisolone. This case suggests that t(8;21)(q22;q22) may participate in the pathogenesis of AML/TMDS, although this type is usually found as one of the chromosomal abnormalities in de novo acute myelogenous leukemia (AML) with maturation. (Internal Medicine 38: 607-611, 1999)