Prevalence of celiac disease and related antibodies in patients diagnosed with irritable bowel syndrome according to the Rome III criteria. A case–control study

• Published in: Neurogastroenterology and motility Vol. 28; no. 7; pp. 994 - 1000
• Main Authors: Sánchez‐Vargas, L. A., Thomas‐Dupont, P., Torres‐Aguilera, M., Azamar‐Jacome, A. A., Ramírez‐Ceervanes, K. L., Aedo‐Garcés, M. R., Meixueiro‐Daza, A., Roesch‐Dietlen, F., Grube‐Pagola, P., Vivanco‐Cid, H., Remes‐Troche, J. M.
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.07.2016
• Subjects: Adult; Autoantibodies - blood; Case-Control Studies; celiac disease; Celiac Disease - blood; Celiac Disease - classification; Celiac Disease - epidemiology; diarrhea; Female; gluten; Humans; Immunoglobulin A - blood; irritable bowel syndrome; Irritable Bowel Syndrome - blood; Irritable Bowel Syndrome - classification; Irritable Bowel Syndrome - epidemiology; Male; Mexico; Middle Aged; Prevalence; Prospective Studies; celiac disease; gluten; Mexico; irritable bowel syndrome; diarrhea
• ISSN: 1350-1925; 1365-2982; 1365-2982
• DOI: 10.1111/nmo.12799

Background The cost‐effectiveness for screening for celiac disease (CD) in patients with irritable bowel syndrome (IBS), specifically in the diarrhea (IBS‐D) subtype, is beneficial if the prevalence is >1%. However, recent studies have shown controversial results. In this large case–control study, our aim was to determine the prevalence of CD and a panel of related antibodies in patients diagnosed with IBS. Materials and methods Four hundred IBS patients (Rome III) and 400 asymptomatic healthy controls were prospectively evaluated using antihuman tissue transglutaminase (h‐tTG IgA) and deamidated gliadin peptide antibodies (DGP II IgA and DGP II IgG). Duodenal biopsy was performed on the patients that were positive for the h‐tTG IgA and/or DGP II IgG antibodies. Results The mean age of the population was 44.47 ± 18.01 years and 335 (82%) of the subjects were women. Twenty‐one patients and six controls had at least one positive test for CD (5.25% VS 1.5%, p = 0.003, OR 3.63 [95% CI 1.4–9.11]). Eighteen patients were positive for h‐tTG and/or DGP‐II IgG. Histologic confirmation of CD was 2.5% in the IBS patients vs 0.5% in the controls (p = 0.04, OR 5.21). The IBS‐D subtype had the highest prevalence for serological positivity (12.7%). Conclusions Up to 5.2% of the patients with IBS according to the Rome III criteria were positive for at least one of the CD‐related antibodies and 2.5% had biopsy‐confirmed CD. Therefore, in our population, screening for CD in subjects with IBS appears to be a reasonable strategy, especially in the IBS‐D subgroup.