Endothelial Function and Chronic Exposure to Air Pollution in Normal Male Subjects

• Published in: Hypertension (Dallas, Tex. 1979) Vol. 50; no. 5; pp. 970 - 976
• Main Authors: Briet, Marie, Collin, Cédric, Laurent, Stéphane, Tan, Alice, Azizi, Michel, Agharazii, Mohsen, Jeunemaitre, Xavier, Alhenc-Gelas, François, Boutouyrie, Pierre
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA American Heart Association, Inc 01.11.2007; Hagerstown, MD Lippincott
• Subjects: Adolescent; Adult; Air Pollutants - pharmacology; Amino Acid Substitution; Arterial hypertension. Arterial hypotension; Biological and medical sciences; Blood and lymphatic vessels; Blood Flow Velocity - drug effects; Blood Flow Velocity - genetics; Blood vessels and receptors; Brachial Artery - drug effects; Brachial Artery - physiology; Cardiology. Vascular system; Cross-Over Studies; Experimental diseases; France; Fundamental and applied biological sciences. Psychology; Genotype; Heterozygote; Homozygote; Humans; Hyperemia - genetics; Kallikreins - genetics; Male; Medical sciences; Nitric Oxide - pharmacology; Potassium, Dietary - pharmacology; Sodium Chloride, Dietary - pharmacology; Sulfur Dioxide - pharmacology; Time; Vasodilation - drug effects; Vasodilation - physiology; Vertebrates: cardiovascular system; France; Europe; France, Paris; Antianginal agent; Human; Nitrogen oxide; ultrasonography■ pathology■ mechanical stresses■ air pollution■ endothelium; Coronary vasodilator agent; Mortality; Brachial artery; Cardiovascular disease; Urban area; Morbidity; Endothelium; Reactive hyperemia; Anatomic pathology; Ischemia; Mechanical stress; brachial arteries; Nitric oxide; Nitroglycerin; Organic nitrate; Echography; Tonometry; Caucasoid
• ISSN: 0194-911X; 1524-4563; 1524-4563
• DOI: 10.1161/HYPERTENSIONAHA.107.095844

Exposure to urban air pollution, ultrafine particles or gases, is associated with acute cardiovascular mortality and morbidity. We investigated the effect of ambient air pollution on endothelial function in 40 healthy white male nonsmokers spontaneously breathing ambient air in Paris, France. Air pollutant levels (nitrogen, sulfur and carbon oxides, and particulate matter) were averaged during the 5 days preceding arterial measurements. Brachial artery endothelium-dependent flow-mediated dilatation and reactive hyperemia induced by hand ischemia and endothelium-independent glyceryl trinitrate dilatation were measured using a radiofrequency-based echo-tracking device at 2-week intervals. Flow-mediated dilatation was independently and negatively correlated with the average levels of sulfur dioxide (P<0.001) and nitrogen monoxide (P<0.01). Sulfur dioxide levels explained 19% of the variance of flow-mediated dilatation. An increase in gaseous pollutants, 2 weeks apart, was significantly associated with a decreased in flow-mediated dilatation. No association was found between air pollutants and glyceryl trinitrate–induced vasodilatation. Reactive hyperemia was significantly and positively correlated with particulate matter with aerodynamic diameters <10 μm and <2.5 μm (P<0.0001 and P<0.001, respectively) and nitrogen dioxide (P<0.01). An increase in particulate matter, 2 weeks apart, was significantly correlated with an increase in reactive hyperemia. Endothelial function was impaired by ordinary levels of pollution in healthy young males, in an urban area, and may be reduced by 50% between the least and the most polluted day. Gaseous pollutants affect large artery endothelial function, whereas particulate matter exaggerates the dilatory response of small arteries to ischemia.