Vaccine Engineering with Dual-Functional Mineral Shell: A Promising Strategy to Overcome Preexisting Immunity

Dual‐functional biomineral–vaccine core–shell nanohybrids are obtained using recombinant adenovirus serotype 5 (rAd5) as templates, which efficiently masks the neutralizing epitope of vaccines and preserve their original immunogenicity. The versatile vaccine hybrid can evade the preexisting anti‐Ad5...

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Published inAdvanced materials (Weinheim) Vol. 28; no. 4; pp. 694 - 700
Main Authors Wang, Xiaoyu, Sun, Caijun, Li, Pingchao, Wu, Tongjin, Zhou, Hangyu, Yang, Dong, Liu, Yichu, Ma, Xiuchang, Song, Zhiyong, Nian, Qinggong, Feng, Liqiang, Qin, Chengfeng, Chen, Ling, Tang, Ruikang
Format Journal Article
LanguageEnglish
Published Germany Blackwell Publishing Ltd 27.01.2016
Subjects
adenovirus
calcium phosphate
Design engineering
Immunity
Nanostructure
Neutralizing
preexisting immunity
Preserves
Recombinant
Strategy
T cells
vaccine engineering
Vaccines
vaccine engineering
T cells
preexisting immunity
calcium phosphate
adenovirus
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Summary:Dual‐functional biomineral–vaccine core–shell nanohybrids are obtained using recombinant adenovirus serotype 5 (rAd5) as templates, which efficiently masks the neutralizing epitope of vaccines and preserve their original immunogenicity. The versatile vaccine hybrid can evade the preexisting anti‐Ad5 immunity, leading to boosted multifunctional antigen‐specific cytokine‐secreting T cell responses and presenting promising applications of vaccine‐material hybrid for the rational design of vaccines.
Bibliography:istex:E90032E1468BBD593A010B458E1E5C3942ABDE61
ark:/67375/WNG-XNWRLRNB-K
National Natural Science Foundation of China - No. 31370923; No. 21201150; No. 21571155; No. 91127003
ArticleID:ADMA201503740
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0935-9648
1521-4095
DOI:10.1002/adma.201503740