Repression of propagation of ehrlich ascites tumors by means of attenuating tumor cells

RNA obtained from Ehrlich ascites tumor cells, yeast, rice bran, and soy bean, and derivatives of RNA, as well as their complexes formed with some basic polymers, were examined to evaluate the effectiveness in inhibiting tumors. RNA complexes formed with a certain basic polymer were effective to som...

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Published inCancer Vol. 30; no. 2; pp. 366 - 372
Main Authors Maekawa, Kazuyuki, Kushibe, Masahisa
Format Journal Article
LanguageEnglish
Published New York Wiley Subscription Services, Inc., A Wiley Company 01.08.1972
Subjects
Animals
Carcinoma, Ehrlich Tumor - pathology
Carcinoma, Ehrlich Tumor - prevention & control
Chitin
Depression, Chemical
Edible Grain
Female
Glycine max
Glycols
Imines
Ion Exchange Resins - therapeutic use
Methylation
Mice
Microscopy, Electron
RNA - therapeutic use
RNA, Neoplasm - therapeutic use
Serum Albumin - therapeutic use
Serum Albumin, Bovine - therapeutic use
Ultraviolet Rays
Yeasts
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Summary:RNA obtained from Ehrlich ascites tumor cells, yeast, rice bran, and soy bean, and derivatives of RNA, as well as their complexes formed with some basic polymers, were examined to evaluate the effectiveness in inhibiting tumors. RNA complexes formed with a certain basic polymer were effective to some extent. By means of the pre‐inoculation of tumor cells properly treated with such an RNA complex, the incidence of the tumor was inhibited completely in the challenge inoculation. It could be concluded that the yeast RNA as well as the Ehr. RNA was as effective as the RNA moiety composing the complex.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0008-543X
1097-0142
DOI:10.1002/1097-0142(197208)30:2<366::AID-CNCR2820300210>3.0.CO;2-B