A Review of Prostanoid Receptors: Expression, Characterization, Regulation, and Mechanism of Action

Prostaglandin signaling controls a wide range of biological processes from blood pressure homeostasis to inflammation and resolution thereof to the perception of pain to cell survival. Disruption of normal prostanoid signaling is implicated in numerous disease states. Prostaglandin signaling is faci...

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Bibliographic Details
Published inJournal of cell communication and signaling Vol. 15; no. 2; pp. 155 - 184
Main Author Biringer, Roger G.
Format Journal Article
LanguageEnglish
Published Dordrecht Springer Netherlands 01.06.2021
John Wiley & Sons, Inc
Subjects
Biomedical and Life Sciences
Biomedicine
Blood pressure
Cell Biology
Cell survival
eicosanoid
G protein-coupled receptors
G‐protein
Homeostasis
Isoforms
Life Sciences
Pain perception
prostaglandin
Prostaglandin receptors
prostanoid
receptor
Review
signaling
eicosanoid
prostanoid
G-protein
receptor
signaling
prostaglandin
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Summary:Prostaglandin signaling controls a wide range of biological processes from blood pressure homeostasis to inflammation and resolution thereof to the perception of pain to cell survival. Disruption of normal prostanoid signaling is implicated in numerous disease states. Prostaglandin signaling is facilitated by G-protein-coupled, prostanoid-specific receptors and the array of associated G-proteins. This review focuses on the expression, characterization, regulation, and mechanism of action of prostanoid receptors with particular emphasis on human isoforms.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1873-9601
1873-961X
DOI:10.1007/s12079-020-00585-0