Captopril, an Angiotensin-Converting Enzyme Inhibitor, Induced Pulmonary Infiltration with Eosinophilia

• Published in: Internal Medicine Vol. 35; no. 2; pp. 142 - 145
• Main Authors: WATANABE, Kouki, NISHIMURA, Kazutaka, SHIODE, Masahiro, SEKIYA, Michihito, IKEDA, Shuntarou, INOUE, Yoshikazu, IWANAGA, Chiaki
• Format: Journal Article
• Language: English
• Published: Tokyo The Japanese Society of Internal Medicine 1996; Japanese Society of Internal Medicine
• Subjects: Angiotensin-Converting Enzyme Inhibitors - adverse effects; Angiotensin-Converting Enzyme Inhibitors - therapeutic use; Biological and medical sciences; Biopsy; bronchoalveolar lavage; Bronchoalveolar Lavage Fluid; Captopril - adverse effects; Captopril - therapeutic use; Drug toxicity and drugs side effects treatment; Female; Humans; Hypertension - drug therapy; Lung - diagnostic imaging; Lung - pathology; Lymphocyte Activation; lymphocyte stimulation test; Medical sciences; Middle Aged; Pharmacology. Drug treatments; Pulmonary Eosinophilia - chemically induced; Pulmonary Eosinophilia - diagnosis; Radiography; skin patch test; Skin Tests; Syndrome; Toxicity: respiratory system, ent, stomatology; transbronchial lung biopsy; Case study; Respiratory disease; Enzyme; Peptidyl-dipeptidase A; Toxicity; Eosinophilic pneumonia; Enzyme inhibitor; Hydrolases; Peptidyl-dipeptidases; Proteinases
• ISSN: 0918-2918; 1349-7235
• DOI: 10.2169/internalmedicine.35.142

In this study, we investigated the association between the drug-induced pulmonary infiltration with eosinophilia (PIE) syndrome in a patient with hypertension and the angiotensin-converting enzyme inhibitor (ACE-I) captopril. Although the patient developed diffuse lung field infiltrates accompanied by productive cough and striking peripheral eosinophilia, these symptoms disappeared after termination of the administration of captopril, pronase and cephalexine. Furthermore, the results of the peripheral lymphocyte stimulation test, skin patch test and provocation test under informed consent showed a positive reaction only for captopril. Therefore, this patient was diagnosed as captopril-induced PIE syndrome. (Internal Medicine 35: 142-145, 1996)