Prognostic Value of Hepatorenal Function By Modified Model for End-stage Liver Disease (MELD) Score in Patients Undergoing Tricuspid Annuloplasty

• Published in: Journal of the American Heart Association Vol. 7; no. 14
• Main Authors: Chen, Yan, Liu, Ying-Xian, Seto, Wai-Kay, Wu, Mei-Zhen, Yu, Yu-Juan, Lam, Yui-Ming, Au, Wing-Kuk, Chan, Daniel, Sit, Ko-Yung, Ho, Lai-Ming, Tse, Hung-Fat, Yiu, Kai-Hang
• Format: Journal Article
• Language: English
• Published: England John Wiley and Sons Inc 17.07.2018; Wiley
• Subjects: Aged; Bilirubin - metabolism; Cardiac Valve Annuloplasty; Creatinine - metabolism; End Stage Liver Disease; Female; Humans; International Normalized Ratio; Kidney Function Tests; liver and renal dysfunction; Liver Function Tests; Male; Middle Aged; Model for End‐stage Liver Disease; Original Research; outcome; Prognosis; Proportional Hazards Models; Serum Albumin - metabolism; Severity of Illness Index; tricuspid annuloplasty; tricuspid regurgitation; Tricuspid Valve Insufficiency - surgery; tricuspid regurgitation; Model for End‐stage Liver Disease; liver and renal dysfunction; tricuspid annuloplasty; outcome
• ISSN: 2047-9980; 2047-9980
• DOI: 10.1161/jaha.118.009020

The Model for End-stage Liver Disease excluding international normalized ratio (MELD-XI) score and the modified MELD score with albumin replacing international normalized ratio (MELD-Albumin) score, which reflect both liver and renal function, have been reported as predictors of adverse events in liver and heart disease. Nonetheless, their prognostic value in patients undergoing tricuspid annuloplasty has not been addressed. A total of 394 patients who underwent tricuspid annuloplasty were evaluated. Baseline clinical, laboratory, and echocardiographic parameters were recorded. Adverse outcome was defined as the occurrence of heart failure requiring admission or all-cause mortality. Patients who underwent tricuspid annuloplasty had a high prevalence of preoperative hepatorenal dysfunction that was more common in patients with severe tricuspid regurgitation than those with mild to moderate tricuspid regurgitation. The MELD-XI and MELD-Albumin scores were excellent predictors of 1-year adverse outcome (area under the curve: 0.69 and 0.75, respectively). Kaplan-Meier survival curve demonstrated that a high score on MELD-XI (≥12.0) and MELD-Albumin (≥10.7) was associated with an increased risk of adverse events. During a median follow-up of 40 months, both MELD-XI and MELD-Albumin scores were significantly associated with adverse outcome, even after adjusting for potential confounding factors. Significant improvement of hepatorenal function at 1 year postoperation was noted only in patients who had no adverse events, not in those who experienced an adverse outcome. Both MELD-XI score and MELD-Albumin score can provide useful information to predict adverse outcome in patients undergoing tricuspid annuloplasty. The present study supports monitoring of modified MELD score to improve preoperative risk stratification of these patients.