The wound healing, chronic fibrosis, and cancer progression triad

For decades tumors have been recognized as "wounds that do not heal." Besides the commonalities that tumors and wounded tissues share, the process of wound healing also portrays similar characteristics with chronic fibrosis. In this review, we suggest a tight interrelationship, which is go...

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Published inPhysiological genomics Vol. 46; no. 7; pp. 223 - 244
Main Authors Rybinski, Brad, Franco-Barraza, Janusz, Cukierman, Edna
Format Journal Article
LanguageEnglish
Published United States American Physiological Society 01.04.2014
Subjects
Blood Coagulation
Chronic Disease
Disease Progression
Fibrosis
Humans
Neoplasms - pathology
Systems Biology of Cell State Regulation
Wound Healing
wound healing
desmoplasia
regeneration
cancer
fibrosis
tumor stroma
tumor- or cancer-associated fibroblasts
myofibroblasts
epithelial-to-mesenchymal transition
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Summary:For decades tumors have been recognized as "wounds that do not heal." Besides the commonalities that tumors and wounded tissues share, the process of wound healing also portrays similar characteristics with chronic fibrosis. In this review, we suggest a tight interrelationship, which is governed as a concurrence of cellular and microenvironmental reactivity among wound healing, chronic fibrosis, and cancer development/progression (i.e., the WHFC triad). It is clear that the same cell types, as well as soluble and matrix elements that drive wound healing (including regeneration) via distinct signaling pathways, also fuel chronic fibrosis and tumor progression. Hence, here we review the relationship between fibrosis and cancer through the lens of wound healing.
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B. Rybinski and J. Franco-Barraza contributed equally to this work.
ISSN:1094-8341
1531-2267
DOI:10.1152/physiolgenomics.00158.2013