Network analysis reveals disrupted functional brain circuitry in drug-naive social anxiety disorder

• Published in: NeuroImage (Orlando, Fla.) Vol. 190; pp. 213 - 223
• Main Authors: Yang, Xun, Liu, Jin, Meng, Yajing, Xia, Mingrui, Cui, Zaixu, Wu, Xi, Hu, Xinyu, Zhang, Wei, Gong, Gaolang, Gong, Qiyong, Sweeney, John A., He, Yong
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 15.04.2019; Elsevier Limited
• Subjects: Adolescent; Adult; Anxiety disorders; Brain architecture; Brain mapping; Brain research; Cerebral Cortex - diagnostic imaging; Cerebral Cortex - physiopathology; Connectome; Connectome - methods; Cortex (cingulate); Emotional behavior; Fear; Female; Frontolimbic; Functional magnetic resonance imaging; Functional morphology; Graph theory; Humans; Limbic Lobe - diagnostic imaging; Limbic Lobe - physiopathology; Magnetic Resonance Imaging; Male; Nerve Net - diagnostic imaging; Nerve Net - physiopathology; Network-based statistics; Neural networks; Occipital Lobe - diagnostic imaging; Occipital Lobe - physiopathology; Parahippocampal gyrus; Phobia, Social - diagnostic imaging; Phobia, Social - physiopathology; Prefrontal cortex; Prefrontal Cortex - diagnostic imaging; Prefrontal Cortex - physiopathology; Social anxiety; Social anxiety disorder; Social interactions; Young Adult; China; Social anxiety disorder; Graph theory; Connectome; Network-based statistics; Frontolimbic

Social anxiety disorder (SAD) is a common and disabling condition characterized by excessive fear and avoidance of public scrutiny. Psychoradiology studies have suggested that the emotional and behavior deficits in SAD are associated with abnormalities in regional brain function and functional conne...