Applicability of bacterial cellulose as an alternative to paper points in endodontic treatment

• Published in: Acta biomaterialia Vol. 9; no. 4; pp. 6116 - 6122
• Main Authors: Yoshino, Aya, Tabuchi, Mari, Uo, Motohiro, Tatsumi, Hiroto, Hideshima, Katsumi, Kondo, Seiji, Sekine, Joji
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.04.2013
• Subjects: Absorption; Acetobacter - metabolism; Animals; bacteria; Bacterial cellulose; Biocompatibility; cellulose; Cellulose - chemistry; Cellulose - metabolism; Cellulose - therapeutic use; cotton; decontamination; dental caries; Dental Materials; Dental root canal treatment; drug therapy; drugs; humans; Male; Materials Testing; Rats; Rats, Sprague-Dawley; Root Canal Obturation - methods; Root Canal Preparation - methods; Solution absorption; sterilizing; Tensile strength; tooth pulp; Dental root canal treatment; Bacterial cellulose; Biocompatibility; Solution absorption; Tensile strength
• ISSN: 1742-7061; 1878-7568
• DOI: 10.1016/j.actbio.2012.12.022

Dental root canal treatment is required when dental caries progress to infection of the dental pulp. A major goal of this treatment is to provide complete decontamination of the dental root canal system. However, the morphology of dental root canal systems is complex, and many human dental roots have inaccessible areas. In addition, dental reinfection is fairly common. In conventional treatment, a cotton pellet and paper point made from plant cellulose is used to dry and sterilize the dental root canal. Such sterilization requires a treatment material with high absorbency to remove any residue, the ability to improve the efficacy of intracanal medication and high biocompatibility. Bacterial cellulose (BC) is produced by certain strains of bacteria. In this study, we developed BC in a pointed form and evaluated its applicability as a novel material for dental canal treatment with regard to solution absorption, expansion, tensile strength, drug release and biocompatibility. We found that BC has excellent material and biological characteristics compared with conventional materials, such as paper points (plant cellulose). BC showed noticeably higher absorption and expansion than paper points, and maintained a high tensile strength even when wet. The cumulative release of a model drug was significantly greater from BC than from paper points, and BC showed greater compatibility than paper points. Taken together, BC has great potential for use in dental root canal treatment.