Platypodiol a novel clerodane diterpene from Baccharis platypoda

[Display omitted] There is an urgent need for effective leishmanicidal drugs to replace or supplement those in current use. Our group has been bioprospecting many Brazilian plants looking for potential new ‘hits’ to combat leishmaniasis. We found that Baccharis platypoda was one of the Asteraceae sp...

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Published inTetrahedron letters Vol. 55; no. 35; pp. 4898 - 4900
Main Authors de Souza Moreira, Carolina Paula, de Oliveira, Djalma Menezes, dos Santos, Claudia Nunes, Zani, Carlos Leomar, Alves, Tania Maria de Almeida
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 27.08.2014
Elsevier
Subjects
Asteraceae
Baccharis platypoda
Bioprospecting
Brazil
Chemistry
Chemistry, Organic
Clerodane diterpene
Documents
Drugs
Leishmania (L.) amazonensis
Nuclear magnetic resonance
Physical Sciences
Plants (organisms)
Science & Technology
Tetrahedrons
Leishmania (L.) amazonensis
Baccharis platypoda
Clerodane diterpene
Asteraceae
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Summary:[Display omitted] There is an urgent need for effective leishmanicidal drugs to replace or supplement those in current use. Our group has been bioprospecting many Brazilian plants looking for potential new ‘hits’ to combat leishmaniasis. We found that Baccharis platypoda was one of the Asteraceae species that displayed leishmanicidal activity. We now describe the isolation of the new clerodane diterpene (1), named platypodiol after its ethanolic leaf extract. Its structure was determined by detailed NMR and ESI-TOF/MS/MS experiments. Considering the few publications about this species, this result has increased the phytochemical knowledge about B. platypoda.
Bibliography:ObjectType-Article-1
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ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2014.07.021