GnRH agonist triggering affects the kinetics of embryo development: a comparative study

To evaluate the effects of an ovulation triggering agent, human chorionic gonadotropin (hCG), versus a gonadotropin-releasing hormone agonist (GnRHa) on early embryo development in vitro using a time-lapse system. Retrospective analysis of a prospectively collected database. A total of 739 embryos f...

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Bibliographic Details
Published inJournal of ovarian research Vol. 9; no. 22; p. 22
Main Authors Gurbuz, Ali Sami, Gode, Funda, Uzman, Mehmet Sukru, Ince, Betul, Kaya, Melek, Ozcimen, Necati, Ozcimen, Emel Ebru, Acar, Ali
Format Journal Article
LanguageEnglish
Published England BioMed Central Ltd 08.04.2016
BioMed Central
Subjects
Adult
Azoospermia - therapy
Chorionic gonadotropin
Chorionic Gonadotropin - pharmacology
Chorionic Gonadotropin - therapeutic use
Embryo Culture Techniques
Embryonic development
Embryonic Development - drug effects
Female
Gonadotropin-Releasing Hormone - analogs & derivatives
Gonadotropin-Releasing Hormone - antagonists & inhibitors
Gonadotropin-Releasing Hormone - pharmacology
Humans
Infertility, Female - therapy
Kinetics
Male
Neurohormones
Ovarian Reserve
Ovulation Induction
Physiological aspects
Retrospective Studies
Sperm Injections, Intracytoplasmic
Time-Lapse Imaging
Triptorelin Pamoate - pharmacology
United States
Agonist trigger
Time lapse
Oocyte
Embryo quality
Morphokinetic
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Summary:To evaluate the effects of an ovulation triggering agent, human chorionic gonadotropin (hCG), versus a gonadotropin-releasing hormone agonist (GnRHa) on early embryo development in vitro using a time-lapse system. Retrospective analysis of a prospectively collected database. A total of 739 embryos from 152 infertile couples undergoing intracytoplasmic sperm injection cycles. Embryo culture in a time-lapse incubator (EmbryoScope, Vitrolife, Göteborg, Sweden). Embryo morphokinetic parameters. In the 152 women, 252 embryos were derived from GnRHa-triggered cycles compared with 487 embryos derived from hCG-triggered cycles. Time-lapse analysis revealed that embryos from cycles triggered by a GnRHa cleaved faster than embryos derived from hCG-triggered cycles. Triggering with a GnRHa in in vitro fertilization cycles affects embryo kinetics.
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ISSN:1757-2215
1757-2215
DOI:10.1186/s13048-016-0229-8