A case of lupus vasculopathy presenting favorable renal outcome

• Published in: CEN case reports Vol. 9; no. 1; pp. 74 - 80
• Main Authors: Ishizaki, Yuri, Aizawa, Ayako, Ochiai, Shoko, Minakawa, Akihiro, Miyauchi, Shunichi, Umekita, Kunihiko, Sato, Yuji, Ogawa, Yayoi, Kushida, Yoshio, Okayama, Akihiko, Uesugi, Noriko, Fujimoto, Shouichi
• Format: Journal Article
• Language: English
• Published: Singapore Springer Singapore 01.02.2020
• Subjects: Case Report; Medicine; Medicine & Public Health; Nephrology; Urology; Lupus vasculopathy; Noninflammatory necrotizing vasculopathy; Lupus nephritis
• ISSN: 2192-4449; 2192-4449
• DOI: 10.1007/s13730-019-00431-2

Noninflammatory necrotizing vasculopathy, also referred to as lupus vasculopathy, is not infrequently observed in the pathology of lupus nephritis. It affects vessels causing them to become severely narrowed and occluded by a mechanism involving immune complexes. We experienced a 51-year-old woman with lupus nephritis class IV + V, which was accompanied by lupus vasculopathy. Renal biopsy and light microscopy showed eosinophilic hyaline-like material in the afferent and/or efferent arterioles, which narrowed the lumen, and which were positive for IgG by immunofluorescent analysis. Electron microscopy indicated that amorphous material and endothelial detachment occluded the arterioles. These findings were consistent with those of lupus vasculopathy. We treated the patient with steroids and cyclophosphamide. By the day of discharge, her levels of creatinine and proteinuria had undergone partial remission. Although lupus vasculopathy was implied as a lesion with unfavorable renal prognosis, some recent reports suggest its true renal prognosis is not unfavorable necessarily. Nevertheless, lupus vasculopathy is an important finding in diagnosis in contradiction to other vascular legions in systemic lupus erythematosus. In addition, a standard therapy has also not been established. Therefore, it is important to accumulate cases of lupus vasculopathy to determine its prognosis and develop standard treatments.