Embryonic Heterogeneity of Smooth Muscle Cells in the Complex Mechanisms of Thoracic Aortic Aneurysms

Smooth muscle cells (SMCs) are the major cell type of the aortic wall and play a pivotal role in the pathophysiology of thoracic aortic aneurysms (TAAs). TAAs occur in a region-specific manner with the proximal region being a common location. In this region, SMCs are derived embryonically from eithe...

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Published inGenes Vol. 13; no. 9; p. 1618
Main Authors Ito, Sohei, Lu, Hong S, Daugherty, Alan, Sawada, Hisashi
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 01.09.2022
MDPI
Subjects
aneurysm
Aorta
Aortic aneurysms
cardiac neural crest
Coronary vessels
Development and progression
Embryos
Health aspects
Ligands
Marfan syndrome
Muscle cells
Mutation
Neural crest
Pathophysiology
Phosphorylation
Review
second heart field
Smooth muscle
thoracic aorta
Thorax
United States
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Summary:Smooth muscle cells (SMCs) are the major cell type of the aortic wall and play a pivotal role in the pathophysiology of thoracic aortic aneurysms (TAAs). TAAs occur in a region-specific manner with the proximal region being a common location. In this region, SMCs are derived embryonically from either the cardiac neural crest or the second heart field. These cells of distinct origins reside in specific locations and exhibit different biological behaviors in the complex mechanism of TAAs. The purpose of this review is to enhance understanding of the embryonic heterogeneity of SMCs in the proximal thoracic aorta and their functions in TAAs.
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ISSN:2073-4425
2073-4425
DOI:10.3390/genes13091618