Occurrence of highly fluoroquinolone-resistant and methicillin-resistant Staphylococcus aureus in domestic animals

• Published in: Canadian journal of microbiology Vol. 53; no. 7; pp. 925 - 929
• Main Authors: Lin, A.E, Davies, J.E
• Format: Journal Article
• Language: English
• Published: Ottawa, ON National Research Council of Canada 01.07.2007; NRC Research Press; Canadian Science Publishing NRC Research Press
• Subjects: Animals; Animals, Domestic; Anti-Infective Agents - pharmacology; antibiotic resistance; Biological and medical sciences; Cat Diseases - microbiology; Cats; Chemical properties; Chickens; Ciprofloxacin - pharmacology; community-acquired infections; Community-Acquired Infections - microbiology; Diagnosis; Disease Reservoirs - microbiology; Disease Reservoirs - veterinary; DNA Gyrase - genetics; DNA topoisomerase; dog diseases; Dog Diseases - microbiology; Dogs; Domestic animals; Drug resistance; Drug resistance in microorganisms; Drug Resistance, Multiple, Bacterial; Evaluation; fluoroquinolones; Fluoroquinolones - pharmacology; Fundamental and applied biological sciences. Psychology; genes; Genotype & phenotype; Identification and classification; infections associées aux animaux de compagnie; infections communautaires acquises; isolation; methicillin; Methicillin Resistance; Microbiology; mutants; Mutation; nucleotide sequences; Pathogens; pet-associated infections; Phylogeny; phylogénie de souches; Poultry Diseases - microbiology; Quinolone antibacterial agents; Quinolones; résistance aux antibiotiques; Staphylococcus aureus; Staphylococcus aureus - drug effects; Staphylococcus aureus - genetics; Staphylococcus aureus - isolation & purification; Staphylococcus aureus infections; Staphylococcus infections; strain phylogeny; Zoonoses - microbiology; Canada; Resistance; Antibiotic; Community acquired infection; Animal; Bacteria; Micrococcales; Micrococcaceae; Staphylococcus aureus
• ISSN: 0008-4166; 1480-3275
• DOI: 10.1139/W07-062

We describe phenotypic and genotypic analyses carried out on multidrug-resistant Staphylococcus aureus isolated from domestic animals. The sequence type ST239 methicillin-resistant Staphylococcus aureus isolated from dogs were highly resistant to fluoroquinolones, and new combinations of GyrA and GrlA mutations were identified. These findings are consistent with a role for animal carriage in the dissemination of important human pathogens in the community.