Evaluating antibody response pattern in asymptomatic virus infected pregnant females: Human well-being study

• Published in: Journal of King Saud University. Science Vol. 33; no. 1; p. 101255
• Main Authors: Ali, Ashaq, Rashid, Zubia, Zhou, Jieqiong, Zubair Yousaf, Muhammad, Galani, Saddia, Ashraf, Asma, Al-Ghanim, Khalid A., Al-Suliman, Emin, Ahmed, Zubair, Farooq, Muhammad, Virik, Promy, Kaimkhani, Z.A., Al-Mulhm, Norah, Mahboob, Shahid, Dong, Men, Huang, Qiuxiang
• Format: Journal Article
• Language: English
• Published: Saudi Arabia Elsevier B.V 01.01.2021; The Author(s). Published by Elsevier B.V. on behalf of King Saud University; Elsevier
• Subjects: Asymptomatic; CT scan; Original; Pregnant women; SARS-CoV-2; Serum antibodies; Serum antibodies; SARS-CoV-2; Asymptomatic; Pregnant women; CT scan
• ISSN: 1018-3647; 2213-686X
• DOI: 10.1016/j.jksus.2020.101255

[Display omitted] The ongoing SARS-CoV-2 pandemic infecting millions of people globally has given rise to serious public health threats. The need for early detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in asymptomatic pregnant women is compelling to detect vertical transmission timely. Here, 11 SARS-CoV-2 asymptomatic pregnant cases from Wuhan China were investigated. All the patients were initially tested negative for SARS-CoV-2 on RT-PCR, so a chest CT scan was performed. Also, serum antibody (IgM and IgG) titers were estimated. CT scan of patients revealed typical abnormalities related to SARS-CoV-2, indicating ground-glass opacity and infection lesions suggesting viral pneumonia. Elevated IgM and IgG antibodies levels (p < 0.001) were also noticed in infected patients. Hence, CT imaging and serum antibody response are valuable in the early detection of SARS-CoV-2 in asymptomatic pregnant patients. These might serve as prognostic markers for healthcare professionals, in RT-PCR negative patients, to assess the effect of given treatment by chest CT.