A CCRK-EZH2 epigenetic circuitry drives hepatocarcinogenesis and associates with tumor recurrence and poor survival of patients

• Published in: Journal of hepatology Vol. 62; no. 5; pp. 1100 - 1111
• Main Authors: Feng, Hai, Yu, Zhuo, Tian, Yuan, Lee, Ying-Ying, Li, May S, Go, Minnie Y.Y, Cheung, Yue-Sun, Lai, Paul B.S, Chan, Andrew M.L, To, Ka-Fai, Chan, Henry L.Y, Sung, Joseph J.Y, Cheng, Alfred S.L
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.05.2015
• Subjects: Androgen receptor; Animals; Carcinogenesis - genetics; Carcinoma, Hepatocellular - genetics; Carcinoma, Hepatocellular - pathology; Cell Line, Tumor; Chromatin modifications; Cyclin-Dependent Kinases - genetics; Ectopic Gene Expression; Enhancer of Zeste Homolog 2 Protein; Epigenesis, Genetic; Gastroenterology and Hepatology; Gender disparity; Gene Expression Regulation, Neoplastic; Hepatocellular carcinoma; Humans; Kinase; Liver Neoplasms - genetics; Liver Neoplasms - pathology; Mice; MicroRNAs - genetics; Neoplasm Recurrence, Local - genetics; Polycomb Repressive Complex 2 - genetics; Signal Transduction - genetics; Survival Rate; hepatitis B virus; CCRK; E2F transcription factor 1; T-cell factor; dn; dp; trimethylation of lysine 27 at histone H3; AKT phosphorylation at serine473; androgen receptor; shRNA; p-EZH2 Ser21; HBV; hepatocellular carcinoma; HCC; short-hairpin RNA; AR; diethylnitrosamine; kinase-defective; ARE; Kinase; TCF; p-AR Ser81; Gender disparity; GSK-3β phosphorylation at serine9; RT; androgen-responsive element; glycogen synthase kinase 3β; dominant-positive; polycomb repressive complex 2; cell cycle-related kinase; ChIP; enhancer of zeste homolog 2; reverse transcription; chromatin immunoprecipitation; GSK-3β; dominant-negative; E2F1; KD; p-GSK3β Ser9; WT; siRNA; DEN; small-interfering RNA; p-AKT Ser473; AR phosphorylation at serine81; EZH2 phosphorylation at serine21; PRC2; Chromatin modifications; wild-type; EZH2; H3K27me3; p-EZH2Ser21; Hepatocellular carcinoma; p-AKTSer473; p-ARSer81; p-GSK3βSer9; Androgen receptor
• ISSN: 0168-8278; 1600-0641
• DOI: 10.1016/j.jhep.2014.11.040

Graphical abstract