A facile method for the synthesis of N-(α-aminoacyl) sulfonamides

N-Acylsulfonamide derivatives have important applications in organic synthesis and drug discovery. It was found that many problems occurred preparing amino acid derived N-acylsulfonamides with the commonly used coupling approach in our previous studies. In this paper, we report an efficient approach...

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Bibliographic Details
Published inDrug Discoveries & Therapeutics Vol. 6; no. 2; pp. 62 - 68
Main Authors Wu, Shaolei, Chen, Minglu, Wang, Yutao, Hou, Xuben, Yang, Xinying, Su, Li, Fang, Hao
Format Journal Article
LanguageEnglish
Published Japan International Research and Cooperation Association for Bio & Socio-Sciences Advancement 2012
Subjects
amino acid-derived N-acyl-sulfonamides
Amino Acids - chemistry
Anhydrides - chemistry
Chemistry Techniques, Synthetic - methods
Sulfonamides - chemical synthesis
Sulfonamides - chemistry
Synthesis
the mixed anhydride method
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Summary:N-Acylsulfonamide derivatives have important applications in organic synthesis and drug discovery. It was found that many problems occurred preparing amino acid derived N-acylsulfonamides with the commonly used coupling approach in our previous studies. In this paper, we report an efficient approach to synthesize various amino acids derived N-acylsulfonamides in high yields without any racemization.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1881-7831
1881-784X
DOI:10.5582/ddt.2012.v6.2.62