Current advances of functional phytochemicals in Nicotiana plant and related potential value of tobacco processing waste: A review

• Published in: Biomedicine & pharmacotherapy Vol. 143; p. 112191
• Main Authors: Zou, Xinda, BK, Amrit, Abu-Izneid, Tareq, Aziz, Ahsan, Devnath, Popy, Rauf, Abdur, Mitra, Saikat, Emran, Talha Bin, Mujawah, Adil A.H., Lorenzo, Jose M., Mubarak, Mohammad S., Wilairatana, Polrat, Suleria, Hafiz A.R.
• Format: Journal Article
• Language: English
• Published: France Elsevier Masson SAS 01.11.2021; Elsevier
• Subjects: Animals; Anti-Infective Agents - isolation & purification; Anti-Infective Agents - pharmacology; Antineoplastic Agents, Phytogenic - isolation & purification; Antineoplastic Agents, Phytogenic - pharmacology; Antioxidant activity; Healthy functions; Humans; Intestinal flora; Nicotiana - adverse effects; Nicotiana - chemistry; Phytochemicals; Phytochemicals - isolation & purification; Processing waste; Structure-Activity Relationship; Tobacco; Tobacco Industry; Waste Products - adverse effects; Waste Products - analysis; Tobacco; Phytochemicals; Intestinal flora; Processing waste; Antioxidant activity; Healthy functions
• ISSN: 0753-3322; 1950-6007
• DOI: 10.1016/j.biopha.2021.112191

Tobacco is grown in large quantities worldwide as a widely distributed commercial crop. From the harvest of the field to the process into the final product, a series of procedures generate enormous amount of waste materials that are rarely recycled. In recent years, numerous potential bioactive compounds have been isolated from tobacco, and the molecular regulatory mechanisms related to the performance of some functionalities have been identified. This review describes the source of tobacco waste and expounds a large amount of biomass during the tobacco processing, and the necessity of exploring the reuse of tobacco waste. In addition, the review summarizes the bioactive compounds from tobacco that have been discovered so far, and links them to various functions from tobacco extracts, including anti-inflammatory, antitumor, antibacterial, and antioxidant, thus proving the potential value from tobacco waste reuse. In this regard, nornicotine in tobacco is the culprit of many health issues, while the polyphenols and polysaccharides often contribute to the health benefits of tobacco extract. In addition, it is hard to ignore that realization of these functions of tobacco extracts require the involvement of intestinal flora metabolism, which should be considered in the development of new product dosage forms. [Display omitted] •Bioactive compounds in tobacco waste can become a very useful new raw material.•Tobacco offers potential antibacterial, antifungal, antiparasitic and antitumor activities.•However, harmful substances should be avoided before using tobacco plants.•New technologies and improved extraction methods for tobacco are warranted.