Biodegradable Microparticles for Regenerative Medicine: A State of the Art and Trends to Clinical Application

• Published in: Polymers Vol. 14; no. 7; p. 1314
• Main Authors: Sherstneva, Anastasia A, Demina, Tatiana S, Monteiro, Ana P F, Akopova, Tatiana A, Grandfils, Christian, Ilangala, Ange B
• Format: Journal Article Web Resource
• Language: English
• Published: Switzerland MDPI AG 24.03.2022; MDPI
• Subjects: Biodegradability; biomaterials; By products; Cell adhesion & migration; clinical application; Clinical trials; Cytotoxicity; drug delivery; emulsions; Good Manufacturing Practice; Human health sciences; Medicine; Microparticles; Pharmaceutical industry; Pharmacie, pharmacologie & toxicologie; Pharmacy, pharmacology & toxicology; Polyesters; Polymers; Raw materials; regenerative medicine; Review; scaffolds; Sciences de la santé humaine; Stem cells; Tissue engineering; clinical application; tissue engineering; scaffolds; emulsions; regenerative medicine; microparticles; biomaterials; drug delivery
• ISSN: 2073-4360; 2073-4360
• DOI: 10.3390/polym14071314

Tissue engineering and cell therapy are very attractive in terms of potential applications but remain quite challenging regarding the clinical aspects. Amongst the different strategies proposed to facilitate their implementation in clinical practices, biodegradable microparticles have shown promising outcomes with several advantages and potentialities. This critical review aims to establish a survey of the most relevant materials and processing techniques to prepare these micro vehicles. Special attention will be paid to their main potential applications, considering the regulatory constraints and the relative easiness to implement their production at an industrial level to better evaluate their application in clinical practices.