Oil mixes omega 9, 6 and 3, enriched with seaweed, promoted reduction of thermal burned modulating NF-kB and Ki-67

• Published in: Acta cirurgica brasileira Vol. 30; no. 6; pp. 430 - 438
• Main Authors: Campelo, Ana Paula Bomfim Soares, Campelo, Márcio Wilker Soares, Brito, Gerly Anne de Castro, Jamacaru, Francisco Vagnaldo Fechine, Leitão, Renata Ferreira de Carvalho, Vasconcelos, Paulo Roberto Leitão de
• Format: Journal Article
• Language: English
• Published: Brazil Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia 01.06.2015
• Subjects: Animals; Burn; Burns - drug therapy; Burns - pathology; Cell Proliferation - drug effects; Docosahexenoic Acid. alpha-Linolenic Acid; Drug Combinations; Fatty Acids; Fatty Acids - pharmacology; Fatty Acids, Omega-3 - pharmacology; Fatty Acids, Omega-3 - therapeutic use; Fatty Acids, Omega-6 - pharmacology; Fatty Acids, Omega-6 - therapeutic use; Immunohistochemistry; Ki-67 Antigen - analysis; Ki-67 Antigen - drug effects; Male; NF-kappa B - analysis; NF-kappa B - drug effects; Random Allocation; Rats; Rats, Wistar; Reproducibility of Results; Seaweed; Seaweed - chemistry; Time Factors; Treatment Outcome
• ISSN: 0102-8650; 1678-2674; 0102-8650
• DOI: 10.1590/S0102-865020150060000009

To examine the effects of the oil mixes (ω-9, ω-6 and ω-3) in rats subjected to thermal burn. It was also aimed to assess whether the sources of ω3 would interfere with the effect of such mixes on the thermal injury. Thirty-six rats distributed into five groups: burned + water, burned + isolipid mix, burned + oil mix 1 (ALA), burned + oil mix 2 (ALA + EPA + DHA of fish) and burned + oil mix 3 (ALA + DHA from seaweed). The thermal injury was involving total thickness of skin. After the burns animals received the oil mixes for seven days. The lesions were evaluated by immunohistochemistry. Animals receiving mix 3 showed a smaller extension of the thermal injury as compared to those that were supplemented with other oils mixes. Expression of Ki-67 in the receiving Mix 3 increased as compared to all the other groups. Animals supplemented with mix 3 were able to inhibit NF-κB in injured tissue. Rats received oil mix in which the source of ω3 (ALA+DHA of seaweed) showed inhibition of NF-κB, increase in cell proliferation, and reduction the extension of thermal lesion.