Amelogenin and enamel biomimetics

Mature tooth enamel is acellular and does not regenerate itself. Developing technologies that rebuild tooth enamel and preserve tooth structure is therefore of great interest. Considering the importance of amelogenin protein in dental enamel formation, its ability to control apatite mineralization i...

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Published inJournal of materials chemistry. B, Materials for biology and medicine Vol. 3; no. 16; pp. 3112 - 3129
Main Authors Ruan, Qichao, Moradian-Oldak, Janet
Format Journal Article
LanguageEnglish
Published England 01.01.2015
Subjects
apatite
biomimetics
enamel
humans
mechanical properties
mineralization
phospholipids
proteins
tooth enamel
apatite
enamel reconstruction
self-assembly
biomineralization
biomimetic
enamel
Amelogenin
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Summary:Mature tooth enamel is acellular and does not regenerate itself. Developing technologies that rebuild tooth enamel and preserve tooth structure is therefore of great interest. Considering the importance of amelogenin protein in dental enamel formation, its ability to control apatite mineralization in vitro , and its potential to be applied in fabrication of future bio-inspired dental material this review focuses on two major subjects: amelogenin and enamel biomimetics. We review the most recent findings on amelogenin secondary and tertiary structural properties with a focus on its interactions with different targets including other enamel proteins, apatite mineral, and phospholipids. Following a brief overview of enamel hierarchical structure and its mechanical properties we will present the state-of-the-art strategies in the biomimetic reconstruction of human enamel. Mature tooth enamel is acellular and does not regenerate itself.
Bibliography:Qichao Ruan received his PhD in Materials Science form the Shanghai Institute of Ceramics, Chinese Academy of Sciences (SICCAS) in 2011, under the supervision of Prof. Yingchun Zhu. Since then, he has been working as a postdoctoral researcher in the group of Prof. Janet Moradian-Oldak at the Center for Craniofacial Molecular Biology of the University of Southern California. He has wide research interest in developing biomimetic materials and nanosturctures for biomedical application.
Janet Moradian-Oldak is a professor at the Division of Biomedical Sciences, Herman Ostrow School of Dentistry with a joint appointment in the Biomedical Engineering Department at the USC Viterbi School of Engineering. The main objective of her research is understanding the principles that govern the biomineralization of dental enamel by learning how the intricate matrix of proteins, enzymes and minerals come together to form this remarkable bioceramic. The ultimate goal is to develop new dental materials that more closely mimic the structure and function of natural tooth enamel. Her work has resulted in two US patents and more than 100 articles and book chapters.
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ISSN:2050-750X
2050-7518
2050-7518
DOI:10.1039/c5tb00163c