On intra- and intersubject variabilities of airflow in the human lungs

• Published in: Physics of fluids (1994) Vol. 21; no. 10; pp. 101901 - 101901-17
• Main Authors: Choi, Jiwoong, Tawhai, Merryn H., Hoffman, Eric A., Lin, Ching-Long
• Format: Journal Article
• Language: English
• Published: Melville, NY American Institute of Physics 01.10.2009
• Subjects: Biofluid Mechanics; Biological and medical sciences; Biomechanics. Biorheology; Exact sciences and technology; Fluid dynamics; Fundamental and applied biological sciences. Psychology; Fundamental areas of phenomenology (including applications); Physics; Tissues, organs and organisms biophysics; Turbulence simulation and modeling; Turbulent flows, convection, and heat transfer; Air flow; Large eddy simulation; Lung; Vorticity; Pressure distribution; Numerical simulation; Coherent structures; Pneumodynamics; Modeling; Spectral analysis; Turbulence structure
• ISSN: 1070-6631; 1089-7666
• DOI: 10.1063/1.3247170

The effects of intra- and intersubject variabilities in airway geometry on airflow in the human lungs are investigated by large eddy simulation. The airway models of two human subjects consisting of extra- and intrathoracic airways are reconstructed from CT images. For intrasubject study, airflows at two inspiratory flow rates are simulated on the airway geometries of the same subject with four different levels of truncation. These airway models are the original complete geometry and three geometries obtained by truncating the original one at the subglottis, the supraglottis, and the laryngopharynx, respectively. A comparison of the airflows in the complete geometry model shows that the characteristics of the turbulent laryngeal jet in the trachea are similar regardless of Reynolds number in terms of mean velocities, turbulence statistics, coherent structures, and pressure distribution. The truncated airway models, however, do not produce the similar flow structures observed in the complete geometry. An improved inlet boundary condition is then proposed for the airway model truncated at the laryngopharynx to improve the accuracy of solution. The new boundary condition significantly improves the mean flow. The spectral analysis shows that turbulent characteristics are captured downstream away from the glottis. For intersubject study, although the overall flow characteristics are similar, two morphological factors are found to significantly affect the flows between subjects. These are the constriction ratio of the glottis with respect to the trachea and the curvature and shape of the airways.