Sacubitril/valsartan improves right ventricular function in a real-life population of patients with chronic heart failure: The Daunia Heart Failure Registry

• Published in: International journal of cardiology. Heart & vasculature Vol. 27; p. 100486
• Main Authors: Correale, Michele, Mallardi, Adriana, Mazzeo, Pietro, Tricarico, Lucia, Diella, Claudia, Romano, Valentina, Ferraretti, Armando, Leopizzi, Alessandra, Merolla, Giuseppina, Di Biase, Matteo, Brunetti, Natale Daniele
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 01.04.2020; Elsevier
• Subjects: ARNI; Chronic heart failure; Neprilysin inhibitors; Original Paper; Right ventricular function; Sacubitril valsartan; ARNI; Chronic heart failure; Right ventricular function; Neprilysin inhibitors; Sacubitril valsartan
• ISSN: 2352-9067; 2352-9067
• DOI: 10.1016/j.ijcha.2020.100486

Previous studies and case-series showed improvement in left ventricular (LV) function and reverse remodeling after sacubitril/valsartan therapy in real-world studies. We therefore aimed to evaluate whether also right ventricular (RV) function may improve after sacubitril/valsartan therapy. Sixty consecutive patients with chronic heart failure and NYHA class II-III were followed up for 12 months after therapy with sacubitril/valsartan. Left and (RV) function was assessed at baseline and after 12 months of therapy. At 12-month control, therapy with sacubitril/valsartan was associated with a significant improvement in a series of echo parameters: LVEF (p < 0.05), LV end-systolic volume (p < 0.01), left atrium area (p < 0.05). Right ventricular echo parameters were also improved after sacubitril/valsartan therapy: PAsP (31.0 ± 12.8 vs 34.7 ± 12.5 mmHg, p < 0.05), TAPSE (17.8 ± 3.9 vs 16.5 ± 4.0 mm, p < 0.001); mean PAsP reduction was 3.7 ± 11.4 mmHg (-6.3 ± 37.7%), mean TAPSE increase 1.3 ± 2.5 mm (+9.5 ± 15.7%). Indexed (%) improvement in PAsP (r 0.33, p < 0.01) and TAPSE (r −0.42, p < 0.01) values were proportional to baseline levels. Improvement in PAsP and TAPSE were independent of left ventricular improvements except for PAsP and end-systolic volumes (r 0.44, p < 0.01). In a real world scenario, sacubitril/valsartan was associated with an improved RV function.