Sclerosing Cholangitis Associated with Hypereosinophilic Syndrome

• Published in: Internal Medicine Vol. 36; no. 8; pp. 561 - 564
• Main Authors: ICHIKAWA, Naomi, TANIGUCHI, Atsuo, AKAMA, Hideto, ISHIGURO, Hisataka, KURIHARA, Takeshi, TERAI, Chihiro, KARA, Masako, KASHIWAZAKI, Sadao
• Format: Journal Article
• Language: English
• Published: Tokyo The Japanese Society of Internal Medicine 1997; Japanese Society of Internal Medicine
• Subjects: Adolescent; Biological and medical sciences; Cholangitis, Sclerosing - diagnosis; Cholangitis, Sclerosing - drug therapy; corticosteroid; endoscopic retrograde cholangiopancreatography (ERCP); eosinophilia; Gastroenterology. Liver. Pancreas. Abdomen; Humans; Hypereosinophilic Syndrome - diagnosis; Hypereosinophilic Syndrome - drug therapy; Liver. Biliary tract. Portal circulation. Exocrine pancreas; Male; Medical sciences; Other diseases. Semiology; Prednisone - therapeutic use; ursodeoxycholic acid (UDCA); Ursodeoxycholic Acid - therapeutic use; Human; Cholangiopancreatography; Corticosteroid; Radiodiagnosis; Retrograde; Male; Hemopathy; Biliary tract disease; Eosinophilia; Sclerosis; Case study; Primitive; Treatment; Adolescent; Digestive diseases; Endoscopy; Sclerosing cholangitis
• ISSN: 0918-2918; 1349-7235
• DOI: 10.2169/internalmedicine.36.561

A 15-year-old male with hypereosinophilic syndrome was admitted to our hospital because of general malaise and abnormal liver function tests. Endoscopic retrograde cholangiopancreatography demonstrated bile duct changes consistent with primary sclerosing cholangitis. The patient's liver profile tests returned to normal after treatment with prednisolone and ursodeoxycholic acid. In this case, eosinophils might have played an important role in the pathogenesis of the bile duct lesion. (Internal Medicine 36: 561-564, 1997)