Phytoestrogens, novel dietary supplements for breast cancer

• Published in: Biomedicine & pharmacotherapy Vol. 160; p. 114341
• Main Authors: Huang, Shuo, Qi, Baowen, Yang, Ling, Wang, Xue, Huang, Jing, Zhao, Ya, Hu, Yonghe, Xiao, Wenjing
• Format: Journal Article
• Language: English
• Published: France Elsevier Masson SAS 01.04.2023; Elsevier
• Subjects: Breast cancer; Breast Neoplasms - drug therapy; Breast Neoplasms - metabolism; Breast Neoplasms - prevention & control; Dietary Supplements; Estrogens - metabolism; Female; G protein-coupled estrogen receptor; Humans; Phytoestrogens; Phytoestrogens - pharmacology; Phytoestrogens - therapeutic use; Receptors, Estrogen - metabolism; Selective Estrogen Receptor Modulators - therapeutic use; Signing pathway; Phytoestrogens; HB-EGF; PLC; cAMP; HIF2; E2; EGFR; CTGF; PI3K; TNBCs; GPER/GPR30; AC; ERs; CAF; Breast cancer; Signing pathway; IARC; Akt; MAPK; PRs; PMCA4; SERMs; VEGFR-2; G protein-coupled estrogen receptor; VEGFs; HER2; PMCA2; TCM; ERK
• ISSN: 0753-3322; 1950-6007
• DOI: 10.1016/j.biopha.2023.114341

While endocrine therapy is considered as an effective way to treat breast cancer, it still faces many challenges, such as drug resistance and individual discrepancy. Therefore, novel preventive and therapeutic modalities are still in great demand to decrease the incidence and mortality rate of breast cancer. Numerous studies suggested that G protein-coupled estrogen receptor (GPER), a membrane estrogen receptor, is a potential target for breast cancer prevention and treatment. It was also shown that not only endogenous estrogens can activate GPERs, but many phytoestrogens can also function as selective estrogen receptor modulators (SERMs) to interact GPERs. In this review, we discussed the possible mechanisms of GPERs pathways and shed a light of developing novel phytoestrogens based dietary supplements against breast cancers. [Display omitted] •GPER is a key target to treat breast cancer, but the mechanisms are still under investigations.•Phytoestrogens have bidirectional regulatory effects on breast cancers.•Phytoestrogens have different binding mode to GPER.•The impart of phytoestrogens on breast cancer depend on whether they activates or inhibits GPER.•The development of appropriate phytoestrogen dietary supplements is of great significance.