Influence of the microenvironment on cell fate determination and migration

Several critical cell functions are influenced not only by internal cellular machinery but also by external mechanical and biochemical cues from the surrounding microenvironment. Slight changes to the microenvironment can result in dramatic changes to the cell's phenotype; for example, a change...

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Bibliographic Details
Published inPhysiological genomics Vol. 46; no. 9; pp. 309 - 314
Main Authors Bloom, Alexander B, Zaman, Muhammad H
Format Journal Article
LanguageEnglish
Published United States American Physiological Society 01.05.2014
Subjects
Cell Adhesion - physiology
Cell Culture Techniques - methods
Cell Differentiation - physiology
Cell Movement - physiology
Cellular Microenvironment - physiology
General Interest
Mechanotransduction, Cellular - physiology
Models, Biological
cell migration
computational modeling
cell adhesion
cell fate
extracellular matrix
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Summary:Several critical cell functions are influenced not only by internal cellular machinery but also by external mechanical and biochemical cues from the surrounding microenvironment. Slight changes to the microenvironment can result in dramatic changes to the cell's phenotype; for example, a change in the nutrients or pH of a tumor microenvironment can result in increased tumor metastasis. While cellular fate and the regulators of cell fate have been studied in detail for several decades now, our understanding of the extracellular regulators remains qualitative and far from comprehensive. In this review, we discuss the microenvironment influence on cell fate in terms of adhesion, migration, and differentiation and focus on both developments in experimental and computation tools to analyze cellular fate.
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ISSN:1094-8341
1531-2267
DOI:10.1152/physiolgenomics.00170.2013