Common matrix metalloproteinase 2 gene haplotypes may modulate left ventricular remodelling in hypertensive patients

• Published in: Journal of human hypertension Vol. 26; no. 3; pp. 171 - 177
• Main Authors: LACCHINI, R, JACOB-FERREIRA, Alb, LUIZON, M. R, GASPARINI, S, FERREIRA-SAE, Mcs, SCHREIBER, R, NADRUZ, W, TANUS-SANTOS, J. E
• Format: Journal Article
• Language: English
• Published: Basingstoke Nature Publishing Group 01.03.2012
• Subjects: Adult; Aged; Arterial hypertension. Arterial hypotension; Biological and medical sciences; Blood and lymphatic vessels; Cardiology. Vascular system; Care and treatment; Echocardiography; Experimental diseases; Female; Gelatinase A; Gene polymorphism; Genetic aspects; Haplotypes; Haplotypes - genetics; Health aspects; Heart; Heart ventricle, Left; Humans; Hypertension; Hypertension - complications; Hypertension - diagnostic imaging; Hypertension - pathology; Hypertrophy, Left Ventricular - diagnostic imaging; Hypertrophy, Left Ventricular - genetics; Hypertrophy, Left Ventricular - pathology; Male; Matrix metalloproteinase; Matrix Metalloproteinase 2 - genetics; Medical sciences; Metalloproteinase; Metalloproteins; Middle Aged; Phenotypes; Polymorphism, Genetic; Ventricle; Ventricular Remodeling - genetics; Brazil; Human; Hypertension; Heart remodelling; left ventricular hypertrophy; MMP-2 haplotypes; Cardiovascular disease; Haplotype; Left ventricle; MMP-2 polymorphisms; Polymorphism

Matrix metalloproteinases (MMPs) are involved in cardiac remodelling. We examined whether MMP-2 genetic polymorphisms are associated with hypertension and left ventricular (LV) remodelling in hypertensive patients. We studied 160 hypertensive patients and 123 healthy controls. Echocardiography was p...