Common matrix metalloproteinase 2 gene haplotypes may modulate left ventricular remodelling in hypertensive patients

• Published in: Journal of human hypertension Vol. 26; no. 3; pp. 171 - 177
• Main Authors: LACCHINI, R, JACOB-FERREIRA, Alb, LUIZON, M. R, GASPARINI, S, FERREIRA-SAE, Mcs, SCHREIBER, R, NADRUZ, W, TANUS-SANTOS, J. E
• Format: Journal Article
• Language: English
• Published: Basingstoke Nature Publishing Group 01.03.2012
• Subjects: Adult; Aged; Arterial hypertension. Arterial hypotension; Biological and medical sciences; Blood and lymphatic vessels; Cardiology. Vascular system; Care and treatment; Echocardiography; Experimental diseases; Female; Gelatinase A; Gene polymorphism; Genetic aspects; Haplotypes; Haplotypes - genetics; Health aspects; Heart; Heart ventricle, Left; Humans; Hypertension; Hypertension - complications; Hypertension - diagnostic imaging; Hypertension - pathology; Hypertrophy, Left Ventricular - diagnostic imaging; Hypertrophy, Left Ventricular - genetics; Hypertrophy, Left Ventricular - pathology; Male; Matrix metalloproteinase; Matrix Metalloproteinase 2 - genetics; Medical sciences; Metalloproteinase; Metalloproteins; Middle Aged; Phenotypes; Polymorphism, Genetic; Ventricle; Ventricular Remodeling - genetics; Brazil; Human; Hypertension; Heart remodelling; left ventricular hypertrophy; MMP-2 haplotypes; Cardiovascular disease; Haplotype; Left ventricle; MMP-2 polymorphisms; Polymorphism
• ISSN: 0950-9240; 1476-5527
• DOI: 10.1038/jhh.2011.8

Matrix metalloproteinases (MMPs) are involved in cardiac remodelling. We examined whether MMP-2 genetic polymorphisms are associated with hypertension and left ventricular (LV) remodelling in hypertensive patients. We studied 160 hypertensive patients and 123 healthy controls. Echocardiography was performed in all patients and the C(-1306)T (rs243865) and C(-735)T (rs 2285053) MMP-2 polymorphisms were analysed. Haplo.stats analysis was used to evaluate whether MMP-2 haplotypes are associated with hypertension and with extremes in LV mass index (LVMI). Multiple linear regression analysis was performed to assess whether MMP-2 genotypes or haplotypes affect LVMI and other echocardiography parameters. The C(-1306)T 'CC' genotype was associated with reduced LVMI and LV end-diastolic diameter (EDD) (P=0.0365 and P=0.0438, respectively). The haplotype 'C, C' was associated with reduced LVMI and EDD (P=0.0278 and P=0.0322, respectively). The comparison of upper and lower extremes of the LVMI phenotype showed that the 'C, C' haplotype was more common in the lower LVMI group (P=0.0060), whereas the 'T, C' haplotype was more common in the higher quartile of LVMI (P=0.0187), and this haplotype was associated with increased risk of higher LVMI values (odds ratio=3.5121, 95% confidence interval=1.3193-9.3494). The findings suggest that MMP-2 polymorphisms affect hypertension-induced LV remodelling.