Hepatoblastoma: A Need for Cell Lines and Tissue Banks to Develop Targeted Drug Therapies

Limited research exists regarding the most aggressive forms of hepatoblastoma. Cell lines of the rare subtypes of hepatoblastoma with poor prognosis are not only difficult to attain but also challenging to characterize histologically. A community-driven approach to educating parents and families, re...

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Published inFrontiers in pediatrics Vol. 4; p. 22
Main Authors Rikhi, Rishi Raj, Spady, Kimberlee K, Hoffman, Ruth I, Bateman, Michael S, Bateman, Max, Howard, Lisa Easom
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 21.03.2016
Subjects
cell lines
Hepatoblastoma
Pediatrics
Roadmap
Tissue procurement
xenograft models
hepatoblastoma
roadmap
cell lines
xenograft models
tissue procurement
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Summary:Limited research exists regarding the most aggressive forms of hepatoblastoma. Cell lines of the rare subtypes of hepatoblastoma with poor prognosis are not only difficult to attain but also challenging to characterize histologically. A community-driven approach to educating parents and families, regarding the need for donated tissue, is necessary for scientists to have access to resources for murine models and drug discovery. Herein, we describe the currently available resources, existing gaps in research, and the path to move forward for uniform cure of hepatoblastoma.
Bibliography:ObjectType-Article-2
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ObjectType-Review-1
Specialty section: This article was submitted to Pediatric Oncology, a section of the journal Frontiers in Pediatrics
Reviewed by: Steven G. Gray, Trinity College Dublin, Ireland; Jeffrey Toretsky, Georgetown University, USA
Edited by: Anat Erdreich-Epstein, Children’s Hospital Los Angeles and University of Southern California, USA
ISSN:2296-2360
2296-2360
DOI:10.3389/fped.2016.00022