Detection of deoxygenation-related signal change in acute ischemic stroke patients by T2-weighted magnetic resonance imaging

• Published in: Stroke (1970) Vol. 33; no. 4; pp. 967 - 971
• Main Authors: TAMURA, Hajime, HATAZAWA, Jun, TOYOSHIMA, Hideto, SHIMOSEGAWA, Eku, OKUDERA, Toshio
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 01.04.2002; American Heart Association, Inc
• Subjects: Acute Disease; Adult; Aged; Aged, 80 and over; Biological and medical sciences; Brain - blood supply; Brain - pathology; Brain - physiopathology; Brain Ischemia - complications; Brain Ischemia - diagnosis; Brain Ischemia - physiopathology; Cerebrovascular Circulation; Female; Humans; Image Enhancement; Magnetic Resonance Angiography - methods; Magnetic Resonance Imaging - methods; Male; Medical sciences; Middle Aged; Neurology; Oxygen - metabolism; Predictive Value of Tests; Retrospective Studies; Sensitivity and Specificity; Stroke - complications; Stroke - diagnosis; Stroke - physiopathology; Vascular diseases and vascular malformations of the nervous system; Human; Nervous system diseases; Stroke; Acute; Cardiovascular disease; Exploration; Method; Metabolism; Nuclear magnetic resonance imaging; Cerebral disorder; Vascular disease; Ischemia; Central nervous system disease; Deoxygenation; Medical imagery; Adult; Oxygenation; Cerebrovascular disease
• ISSN: 0039-2499; 1524-4628
• DOI: 10.1161/01.STR.0000013672.70986.E2

Acute decreases in the MR T2*-weighted signal have been reported in experimental models of middle cerebral artery occlusion. This has been attributed to blood deoxygenation in association with an increased brain oxygen extraction fraction. The aim of this study was to detect this signal by susceptibility-weighted MR imaging in acute ischemic stroke patients. Dynamic susceptibility contrast-enhanced MR (DSC-MR) imaging was performed within 4 hours of stroke onset in 6 patients with unilateral cerebral artery occlusion (middle cerebral artery, n=5; internal carotid artery, n=1). Cerebral blood volume was estimated on a pixel-by-pixel basis. DSC-MR images taken before arrival of the contrast medium were examined visually to identify hypointense areas. Bilateral regions of interest were set in the middle cerebral artery territory for comparison of the mean signal intensity. A semilogarithmic plot of signal intensity versus cerebral blood volume for every pixel in the region of interest was also analyzed. The side on which the hypointense area was seen was significantly correlated with the side of arterial occlusion. The mean signal intensity was significantly smaller on the affected side than on the contralateral side. The semilogarithmic plot of signal intensity versus cerebral blood volume indicated greater deoxyhemoglobin concentrations for the ipsilateral than for the contralateral region of interest. DSC-MR images allow detection of hypointensity in the affected cerebral hemisphere in acute ischemic stroke patients. Such hypointensity may indicate increased oxygen extraction fraction (misery perfusion) and may provide information valuable to patient care.