Chinese medicines in the treatment of experimental diabetic nephropathy

Diabetic nephropathy (DN) is a severe micro vascular complication accompanying diabetes mellitus that affects millions of people worldwide. End-stage renal disease occurs in nearly half of all DN patients, resulting in large medical costs and lost productivity. The course of DN progression is compli...

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Published inChinese medicine Vol. 11; no. 6; p. 6
Main Authors Liu, Jing-Yi, Chen, Xiao-Xin, Tang, Sydney Chi-Wai, Sze, Stephen Cho-Wing, Feng, Yi-Bin, Lee, Kai-Fai, Zhang, Kalin Yan-Bo
Format Journal Article
LanguageEnglish
Published England BioMed Central Ltd 24.02.2016
BioMed Central
Subjects
Analysis
Care and treatment
Diabetes
Diabetic nephropathies
Drugs
Kidney diseases
Medicine, Chinese
Metabolism
Pathogenesis
Review
Rodents
Studies
Treatment outcome
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Summary:Diabetic nephropathy (DN) is a severe micro vascular complication accompanying diabetes mellitus that affects millions of people worldwide. End-stage renal disease occurs in nearly half of all DN patients, resulting in large medical costs and lost productivity. The course of DN progression is complicated, and effective and safe therapeutic strategies are desired. While the complex nature of DN renders medicines with a single therapeutic target less efficacious, Chinese medicine, with its holistic view targeting the whole system of the patient, has exhibited efficacy for DN management. This review aims to describe the experimental evidence for Chinese medicines in DN management, with an emphasis on the underlying mechanisms, and to discuss the combined use of herbs and drugs in DN treatment.
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ISSN:1749-8546
1749-8546
DOI:10.1186/s13020-016-0075-z