Palladium Nanoparticles Supported on Sulfonic Acid Functionalized Silica as Trifunctional Heterogeneous Catalysts for Heck and Suzuki Reactions

• Published in: ChemCatChem Vol. 7; no. 14; pp. 2085 - 2094
• Main Authors: Oger, Nicolas, Le Grognec, Erwan, Felpin, François-Xavier
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY-VCH Verlag 13.07.2015; WILEY‐VCH Verlag; Wiley Subscription Services, Inc; Wiley
• Subjects: acidity; Catalysis; Chemical Sciences; CC coupling; diazo compounds; multicomponent reactions; palladium
• ISSN: 1867-3880; 1867-3899; 1867-3899
• DOI: 10.1002/cctc.201500179

The arylation of acrylates and boronic acids with anilines, through in situ generated aryl diazonium salts, was successfully achieved by using trifunctional heterogeneous catalysts bearing Brønsted acid and metal active sites. The trifunctional materials were prepared by adsorption of palladium nanoparticles, generated by reduction of a solution of Pd(OAc)2 onto a commercially available sulfonic acid functionalized silica. These new trifunctional catalysts act as a 1) proton donor for the diazotization step, 2) counterion for the diazonium salt, and 3) Pd source for the coupling step. This unprecedented strategy, features mild and safe conditions as hazardous aryl diazonium salts are generated in situ and only produces environmentally friendly byproducts such as tBuOH, H2O, and N2. One, two, three in one! Trifunctional catalysts prepared by adsorption of palladium nanoparticles onto a commercially available sulfonic acid functionalized silica act as proton donor for diazotization, counterion for the diazonium salt, and Pd source for coupling reactions. This strategy produces environmentally friendly byproducts only.