Cytomegalovirus Hemorrhagic Cystitis in a Malignant Glioma Patient Treated with Temozolomide

Temozolomide, a key drug in the treatment of malignant glioma, can cause profound lymphopenia and various opportunistic infectious diseases. A 79-year-old woman with anaplastic oligodendroglioma developed a fever and gross hematuria after 8 weeks of standard radiotherapy with concomitant temozolomid...

Full description

Saved in:
Bibliographic Details
Published inInternal Medicine Vol. 57; no. 20; pp. 3047 - 3050
Main Authors Furukawa, Ryutaro, Homma, Hirokuni, Inoue, Tomohiro, Horiuchi, Hajime, Usui, Kazuhiro
Format Journal Article
LanguageEnglish
Published Japan The Japanese Society of Internal Medicine 15.10.2018
Japan Science and Technology Agency
Subjects
Adult
Aged
Antigenemia
Antineoplastic Agents, Alkylating - adverse effects
Antineoplastic Agents, Alkylating - therapeutic use
Antiviral Agents - therapeutic use
Brain cancer
Case Report
Cystitis
Cystitis - chemically induced
Cystitis - drug therapy
Cytology
Cytomegalovirus
Cytomegalovirus Infections - chemically induced
Cytomegalovirus Infections - drug therapy
Female
Fever
Ganciclovir
Glioma
Glioma - drug therapy
Hematuria
Hemorrhage
Hemorrhagic cystitis
Humans
Infectious diseases
Internal medicine
Leukocytes
Lymphopenia
malignant glioma
Oligodendroglioma
Opportunistic Infections - chemically induced
Opportunistic Infections - drug therapy
Pp65 protein
Radiation therapy
Temozolomide
Temozolomide - adverse effects
Temozolomide - therapeutic use
Treatment Outcome
Urine
temozolomide
hemorrhagic cystitis
cytomegalovirus
malignant glioma
Online AccessGet full text

Cover

More Information
Summary:Temozolomide, a key drug in the treatment of malignant glioma, can cause profound lymphopenia and various opportunistic infectious diseases. A 79-year-old woman with anaplastic oligodendroglioma developed a fever and gross hematuria after 8 weeks of standard radiotherapy with concomitant temozolomide treatment. A cytomegalovirus (CMV) antigen test for pp65 antigenemia was positive (137 cells per 75,800 leukocytes), and the findings from a urine cytology test were consistent with CMV-induced hemorrhagic cystitis. She was treated with ganciclovir, and her condition improved. CMV monitoring is needed when patients develop symptoms related to opportunistic infections during temozolomide treatment for malignant glioma.
Bibliography:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
ObjectType-Feature-4
content type line 23
ObjectType-Report-1
ObjectType-Article-3
Correspondence to Dr.　Ryutaro Furukawa, rfurukawa-tky@umin.ac.jp
ISSN:0918-2918
1349-7235
DOI:10.2169/internalmedicine.1005-18