Marine Natural Products. XXIII. : Three New Cytotoxic Dimeric Macrolides, Swinholides B and C and Isoswinholide A, Congeners of Swinholide A, from the Okinawan Marine Sponge Theonella swinhoei

Following the characterization of swinholide A (1), the major cytotoxic dimeric macrolide, three new congeneric dimeric macrolides, named swinholide B (2), swinholide C (3), and isoswinholide A (10), have been isolated from the Okinawa marine sponge Theonella swinhoei. The structures of these dimeri...

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Bibliographic Details
Published inChemical & pharmaceutical bulletin Vol. 38; no. 11; pp. 2960 - 2966
Main Authors KOBAYASHI, Motomasa, TANAKA, Jun-ichi, KATORI, Taketo, KITAGAWA, Isao
Format Journal Article
LanguageEnglish
Published Tokyo The Pharmaceutical Society of Japan 1990
Maruzen
Subjects
Analytical, structural and metabolic biochemistry
Animals
Antineoplastic Agents - isolation & purification
Biological and medical sciences
cytotoxicity
dimeric macrolide
Fundamental and applied biological sciences. Psychology
Heterocyclic compounds, pigments
isoswinholide A
marine sponge
Marine Toxins - isolation & purification
Marine Toxins - pharmacology
Miscellaneous
Other biological molecules
Porifera - analysis
swinholide A
swinholide B
swinholide C
Theonella swinhoei
Molecular structure
Porifera
Cytotoxicity
Isolation
Dimer
Invertebrata
Macrolide
Biological activity
Physicochemical properties
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Summary:Following the characterization of swinholide A (1), the major cytotoxic dimeric macrolide, three new congeneric dimeric macrolides, named swinholide B (2), swinholide C (3), and isoswinholide A (10), have been isolated from the Okinawa marine sponge Theonella swinhoei. The structures of these dimeric macrolides have been elucidated on the basis of chemical and physiocochemical evidence. These dimeric macrolides were shown to exhiit potent cytotoxicities toward KB cell lines.
ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.38.2960