Wastewater-based surveillance in Italy leading to the first detection of mcr-10-positive Klebsiella quasipneumoniae

Wastewater-based surveillance enabled the first detection of the mobile colistin resistance gene mcr-10 in Italy. This plasmid-borne resistance gene was found in strains of Klebsiella quasipneumoniae isolated from samples of human raw sewage collected over several months. Although the isolates were...

Full description

Saved in:
Bibliographic Details
Published inAntimicrobial resistance & infection control Vol. 11; no. 1; p. 155
Main Authors Formenti, Nicoletta, Guarneri, Flavia, Bertasio, Cristina, Parisio, Giovanni, Romeo, Claudia, Scali, Federico, Birbes, Laura, Boniotti, Maria Beatrice, Diegoli, Giuseppe, Candela, Loredana, Romeo, Gianluca Antonio, Pasquali, Paolo, Alborali, Giovanni Loris
Format Journal Article
LanguageEnglish
Published England BioMed Central Ltd 09.12.2022
BioMed Central
BMC
Subjects
AMR surveillance
Anti-Bacterial Agents - pharmacology
Antibacterial agents
Antimicrobial agents
Antimicrobial resistance
Beta lactamases
Brief Report
Cellulose acetate
Colistin
Colistin - pharmacology
Disease control
Drug resistance
Drug resistance in microorganisms
E coli
Genes
Humans
Klebsiella - genetics
Klebsiella quasipneumoniae similpneumoniae
Mutation
Plasmid gene
Plasmids
Severe acute respiratory syndrome coronavirus 2
Sewage
Wastewater
Wastewater-Based Epidemiological Monitoring
Italy
China
Antimicrobial resistance
Colistin
Plasmid gene
Wastewater
AMR surveillance
Klebsiella quasipneumoniae similpneumoniae
Online AccessGet full text

Cover

More Information
Summary:Wastewater-based surveillance enabled the first detection of the mobile colistin resistance gene mcr-10 in Italy. This plasmid-borne resistance gene was found in strains of Klebsiella quasipneumoniae isolated from samples of human raw sewage collected over several months. Although the isolates were phenotypically susceptible to colistin, the emergence of mcr-10 is concerning due to the highly variable expression of the gene and the potential for horizontal transfer to other species. In addition, the strains also carried an extended-spectrum β-lactamase gene and were phenotypically resistant to several beta-lactams. This study highlights the value of wastewater-based surveillance as an effective tool to monitor the emergence of antimicrobial resistance in strains circulating in the community and the environment.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:2047-2994
2047-2994
DOI:10.1186/s13756-022-01194-9