Virus entry: molecular mechanisms and biomedical applications

Viruses have evolved to enter cells from all three domains of life--Bacteria, Archaea and Eukaryotes. Of more than 3,600 known viruses, hundreds can infect human cells and most of those are associated with disease. To gain access to the cell interior, animal viruses attach to host-cell receptors. Ad...

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Bibliographic Details
Published inNature reviews. Microbiology Vol. 2; no. 2; pp. 109 - 122
Main Author Dimitrov, Dimiter S
Format Journal Article
LanguageEnglish
Published England Nature Publishing Group 01.02.2004
Nature Publishing Group UK
Subjects
Acids
Adenoviruses
Animals
Antibodies, Viral - immunology
Bacteria
Blood groups
Cancer
Disease
Ebola virus
Encephalitis
Fever
Gastroenteritis
Genomes
Hepatitis
HIV
Human immunodeficiency virus
Humans
Influenza
Lipids
Membrane Fusion
Protein Conformation
Proteins
Rabies
Receptors, Virus - chemistry
Receptors, Virus - physiology
Vaccines
Viral Vaccines - immunology
Viruses
Viruses - pathogenicity
Viruses - ultrastructure
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Summary:Viruses have evolved to enter cells from all three domains of life--Bacteria, Archaea and Eukaryotes. Of more than 3,600 known viruses, hundreds can infect human cells and most of those are associated with disease. To gain access to the cell interior, animal viruses attach to host-cell receptors. Advances in our understanding of how viral entry proteins interact with their host-cell receptors and undergo conformational changes that lead to entry offer unprecedented opportunities for the development of novel therapeutics and vaccines.
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ISSN:1740-1526
1740-1534
DOI:10.1038/nrmicro817