Hyperlipoproteinemia in rats fed polychlorinated biphenyls

• Published in: Journal of Nutritional Science and Vitaminology Vol. 36; no. 2; pp. 117 - 122
• Main Authors: Oda, H. (Nagoya Univ. (Japan). Faculty of Agriculture), Matsushita, N, Hirabayashi, A, Yoshida, A
• Format: Journal Article
• Language: English
• Published: Japan Center for Academic Publications Japan 1990
• Subjects: Animals; Apolipoprotein A-I; Apolipoproteins A - blood; Apolipoproteins B - blood; BIFENILOS POLICLORADOS; CHOLESTEROL; Cholesterol, Dietary - administration & dosage; Cholesterol, Dietary - adverse effects; Cholesterol, HDL - blood; Cholesterol, VLDL - blood; COLESTEROL; Disease Models, Animal; high density lipoprotein; Hyperlipoproteinemias - chemically induced; LIPOPROTEINAS; LIPOPROTEINE; LIPOPROTEINS; Male; PCB; POLYCHLORINATED BIPHENYLS; Polychlorinated Biphenyls - administration & dosage; Polychlorinated Biphenyls - toxicity; POLYCHLORURE DE BIPHENYLE; RAT; RATA; RATS; Rats, Inbred Strains
• ISSN: 0301-4800; 1881-7742
• DOI: 10.3177/jnsv.36.117

Hypercholesterolemia due to feeding of polychlorinated biphenyls (PCB) and due to feeding of high cholesterol was compared. Rats in control group were fed a 25% casein diet, and those in PCB group or cholesterol group were fed the 25% casein diet supplemented with 0.03% PCB or 1% cholesterol and 0.25% cholic acid, respectively. Lipo-protein mass (d<1.21g/ml) was higher 1.9- and 1.3-fold in rats fed PCB and cholesterol, respectively, as compared with controls. In rats fed PCB, protein, cholesterol, and phospholipid in the lipoprotein fraction markedly increased. Cholesterol-feeding resulted in the increase in pre-β-lipoprotein cholesterol, while PCB-feeding increased α-lipoprotein cholesterol and slightly slow migrated pre-β-lipoprotein cholesterol. PCB-treated rats had more apolipoprotein A-I in the lipoprotein fraction than control and cholesterol-fed rats. The data demonstrated that hyperlipoproteinemia induced by PCB is a novel α-lipoproteinemia and a useful model for investigating metabolism of high density lipoprotein.