Effect of erythorbic acid administration on activities of drug metabolic enzyme and phosphatases in guinea pigs administered an adequate amount of ascorbic acid
The effect of erythorbic acid (ErA) administration on activities of liver aniline hydroxylase, liver acid phosphatase, and serum alkaline phosphatase, and the content of liver cytochrome P-450 was studied to determine whether or not ErA would affect the availability of ascorbic acid (AsA) in normal...
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| Published in | Journal of Nutritional Science and Vitaminology Vol. 35; no. 2; pp. 123 - 131 |
|---|---|
| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
Japan
Center for Academic Publications Japan
01.01.1989
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| Online Access | Get full text |
| ISSN | 0301-4800 1881-7742 |
| DOI | 10.3177/jnsv.35.123 |
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| Abstract | The effect of erythorbic acid (ErA) administration on activities of liver aniline hydroxylase, liver acid phosphatase, and serum alkaline phosphatase, and the content of liver cytochrome P-450 was studied to determine whether or not ErA would affect the availability of ascorbic acid (AsA) in normal and AsA-deficient guinea pigs. In experi-ment I, changes of the enzyme activities and liver cytochrome P-450 content in the guinea pigs administered AsA and/or ErA and sacrificed on days 4, 10, 16, and 30 were examined. Moreover, in experiment II, after 16 days of depletion of AsA, the guinea pigs were administered AsA and/or ErA. These animals were sacrificed on days 0, 4, and 20 of the repletion period, after which the activities of drug metabolic enzyme and phos-phatases and content of cytochrome P-450 during recovery were observed. The enzyme activities and cytochrome P-450 content of AsA-supplemented guinea pigs were similar to those of ErA-supplemented animals and also similar to those of both AsA and ErA-supplemented guinea pigs throughout the experimental period. During the repletion of the AsA-depleted guinea pigs, there were no significant differences in these enzyme activities and cytochrome P-450 content among the animals administered AsA and/or ErA. These results suggested that ErA adminis-tration may not affect the AsA availability in the guinea pigs. |
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| AbstractList | The effect of erythorbic acid (ErA) administration on activities of liver aniline hydroxylase, liver acid phosphatase, and serum alkaline phosphatase, and the content of liver cytochrome P-450 was studied to determine whether or not ErA would affect the availability of ascorbic acid (AsA) in normal and AsA-deficient guinea pigs. In experi-ment I, changes of the enzyme activities and liver cytochrome P-450 content in the guinea pigs administered AsA and/or ErA and sacrificed on days 4, 10, 16, and 30 were examined. Moreover, in experiment II, after 16 days of depletion of AsA, the guinea pigs were administered AsA and/or ErA. These animals were sacrificed on days 0, 4, and 20 of the repletion period, after which the activities of drug metabolic enzyme and phos-phatases and content of cytochrome P-450 during recovery were observed. The enzyme activities and cytochrome P-450 content of AsA-supplemented guinea pigs were similar to those of ErA-supplemented animals and also similar to those of both AsA and ErA-supplemented guinea pigs throughout the experimental period. During the repletion of the AsA-depleted guinea pigs, there were no significant differences in these enzyme activities and cytochrome P-450 content among the animals administered AsA and/or ErA. These results suggested that ErA adminis-tration may not affect the AsA availability in the guinea pigs. The effect of erythorbic acid (ErA) administration on activities of liver aniline hydroxylase, liver acid phosphatase, and serum alkaline phosphatase, and the content of liver cytochrome P-450 was studied to determine whether or not ErA would affect the availability of ascorbic acid (AsA) in normal and AsA-deficient guinea pigs. In experiment I, changes of the enzyme activities and liver cytochrome P-450 content in the guinea pigs administered AsA and/or ErA and sacrificed on days 4, 10, 16, and 30 were examined. Moreover, in experiment II, after 16 days of depletion of AsA, the guinea pigs were administered AsA and/or ErA. These animals were sacrificed on days 0, 4, and 20 of the repletion period, after which the activities of drug metabolic enzyme and phosphatases and content of cytochrome P-450 during recovery were observed. The enzyme activities and cytochrome P-450 content of AsA-supplemented guinea pigs were similar to those of ErA-supplemented animals and also similar to those of both AsA and ErA-supplemented guinea pigs throughout the experimental period. During the repletion of the AsA-depleted guinea pigs, there were no significant differences in these enzyme activities and cytochrome P-450 content among the animals administered AsA and/or ErA. These results suggested that ErA administration may not affect the AsA availability in the guinea pigs.The effect of erythorbic acid (ErA) administration on activities of liver aniline hydroxylase, liver acid phosphatase, and serum alkaline phosphatase, and the content of liver cytochrome P-450 was studied to determine whether or not ErA would affect the availability of ascorbic acid (AsA) in normal and AsA-deficient guinea pigs. In experiment I, changes of the enzyme activities and liver cytochrome P-450 content in the guinea pigs administered AsA and/or ErA and sacrificed on days 4, 10, 16, and 30 were examined. Moreover, in experiment II, after 16 days of depletion of AsA, the guinea pigs were administered AsA and/or ErA. These animals were sacrificed on days 0, 4, and 20 of the repletion period, after which the activities of drug metabolic enzyme and phosphatases and content of cytochrome P-450 during recovery were observed. The enzyme activities and cytochrome P-450 content of AsA-supplemented guinea pigs were similar to those of ErA-supplemented animals and also similar to those of both AsA and ErA-supplemented guinea pigs throughout the experimental period. During the repletion of the AsA-depleted guinea pigs, there were no significant differences in these enzyme activities and cytochrome P-450 content among the animals administered AsA and/or ErA. These results suggested that ErA administration may not affect the AsA availability in the guinea pigs. The effect of erythorbic acid (ErA) administration on activities of liver aniline hydroxylase, liver acid phosphatase, and serum alkaline phosphatase, and the content of liver cytochrome P-450 was studied to determine whether or not ErA would affect the availability of ascorbic acid (AsA) in normal and AsA-deficient guinea pigs. In experiment I, changes of the enzyme activities and liver cytochrome P-450 content in the guinea pigs administered AsA and/or ErA and sacrificed on days 4, 10, 16, and 30 were examined. Moreover, in experiment II, after 16 days of depletion of AsA, the guinea pigs were administered AsA and/or ErA. These animals were sacrificed on days 0, 4, and 20 of the repletion period, after which the activities of drug metabolic enzyme and phosphatases and content of cytochrome P-450 during recovery were observed. The enzyme activities and cytochrome P-450 content of AsA-supplemented guinea pigs were similar to those of ErA-supplemented animals and also similar to those of both AsA and ErA-supplemented guinea pigs throughout the experimental period. During the repletion of the AsA-depleted guinea pigs, there were no significant differences in these enzyme activities and cytochrome P-450 content among the animals administered AsA and/or ErA. These results suggested that ErA administration may not affect the AsA availability in the guinea pigs. |
| Author | Arakawa, N Suzuki, E. (Ochanomizu Univ., Tokyo (Japan). Inst. of Environmental Science for Human Life) Kurata, T |
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| References | 9) Arakawa, N., Suzuki, E., Kurata, T., Otsuka, M., and Inagaki, C. (1986): Effect of erythorbic acid administration on ascorbic acid content in guinea pig tissues. J. Nutr. Sci. Vitaminol., 32, 171-181. 1) Hornig, D. (1982): Impact of marginal vitamin C deficiency. J. Jap. Soc. Clin. Nutr., 3, 127-141. 15) Imai, Y., Ito, A., and Sato, R. (1966): Evidence for biochemically different types of vesicles in the hepatic microsomal fraction. J. Biochem., 60, 417-428. 11) Chatterjee, G. C. (1967): Ascorbic acid requirements of animals, in The Vitamins, Vol. 1, ed. by Sebrell, W. H., Jr., and Harris, R. B., Academic Press, New York, pp. 495-500. 17) Bessey, O. A., Lowry, O. H., and Brock, M. J. (1946): A method for the rapid determination of alkaline phosphatase with five cubic millimeters of serum. J. Biol. Chem., 164, 321-329. 18) Omura, T., and Sato, R. (1964): The carbon monoxide-binding pigment of liver microsomes. J. Biol. Chem., 239, 2370-2378. 7) Perkins, H. R., and Zilva, S. S. (1950): The influence of scurvy and fall in weight in young guinea pigs on the alkaline phosphatase content of the serum and the zones of provisional calcification. Biochem. J, 47, 306-318. 13) Boyle, P. E., Bessey, O. A., and Howe, P. R. (1940): Rate of dentin formation in incisor teeth of guinea pigs on normal and on ascorbic acid-deficient diets. A. M. A. Arch. Pathol., 30, 90-107. 16) Desai, I. D. (1969): Regulation of lysosomal enzymes. I. Adaptive changes in enzyme activities during starvation and refeeding. Can. J. Biochem., 47, 785-790. 6) Omaye, S. T., and Turnbull, J. D. (1980): Effect of ascorbic acid on hem metabolism in hepatic microsomes. Life Sci., 27, 441-449. 10) Suzuki, E., Kurata, T., Koda, M., and Arakawa, N. (1988): Effect of graded doses of erythorbic acid on activities of drug metabolic enzyme and phosphatases in guinea pigs. J. Nutr. Sci. Vitaminol,, 34, 439-447. 19) Lowry, O. H., Rosebrough, N. J., Farr, A. L., and Randall, R. J. (1951): Protein measurement with the Folin phenol reagent. J. Biol. Chem., 193, 265-275. 4) Zannoni, V. G., and Sato, P. H. (1975): Effects of ascorbic acid on microsomal drug metabolism. Ann. N. Y. Acad. Sci., 258, 119-131. 12) Collins, M., and Elvehjem, C. A. (1958): Ascorbic acid requirement of the guinea pig using growth and tissue ascorbic acid concentrations as criteria. J. Nutr., 64, 503-511. 14) National Academy of Sciences. National Research Council, U.S.A. (1978): Nutrient Requirements of Domestic Animals. No. 10, Nutrient Requirements of Laboratory Animals, Third revised edition, pp. 59-69. 5) Turnbull, J. D., and Omaye, S. T. (1980): Synthesis on cytochrome P-450 hem in ascorbic acid-deficient guinea pigs. Biochem. Pharmacol., 29, 1255-1260. 3) Zannoni, V. G., Flynn, E. J., and Lynch, M. (1972): Ascorbic acid and drug metabolism. Biochem. Pharmacol., 21, 1377-1392. 2) Hornig, D., and Weiser, H. (1976): Interaction of erythorbic acid with ascorbic acid catabolism. Int. J. Vitam. Nutr. Res., 46, 40-47. 8) Hoehn, S. K., and Kanfer, J. N. (1978): L-Ascorbic acid and lysosomal acid hydrolase activities of guinea pig liver and brain. Can. J. Biochem., 56, 352-356. |
| References_xml | – reference: 15) Imai, Y., Ito, A., and Sato, R. (1966): Evidence for biochemically different types of vesicles in the hepatic microsomal fraction. J. Biochem., 60, 417-428. – reference: 6) Omaye, S. T., and Turnbull, J. D. (1980): Effect of ascorbic acid on hem metabolism in hepatic microsomes. Life Sci., 27, 441-449. – reference: 19) Lowry, O. H., Rosebrough, N. J., Farr, A. L., and Randall, R. J. (1951): Protein measurement with the Folin phenol reagent. J. Biol. Chem., 193, 265-275. – reference: 14) National Academy of Sciences. National Research Council, U.S.A. (1978): Nutrient Requirements of Domestic Animals. No. 10, Nutrient Requirements of Laboratory Animals, Third revised edition, pp. 59-69. – reference: 7) Perkins, H. R., and Zilva, S. S. (1950): The influence of scurvy and fall in weight in young guinea pigs on the alkaline phosphatase content of the serum and the zones of provisional calcification. Biochem. J, 47, 306-318. – reference: 18) Omura, T., and Sato, R. (1964): The carbon monoxide-binding pigment of liver microsomes. J. Biol. Chem., 239, 2370-2378. – reference: 2) Hornig, D., and Weiser, H. (1976): Interaction of erythorbic acid with ascorbic acid catabolism. Int. J. Vitam. Nutr. Res., 46, 40-47. – reference: 10) Suzuki, E., Kurata, T., Koda, M., and Arakawa, N. (1988): Effect of graded doses of erythorbic acid on activities of drug metabolic enzyme and phosphatases in guinea pigs. J. Nutr. Sci. Vitaminol,, 34, 439-447. – reference: 12) Collins, M., and Elvehjem, C. A. (1958): Ascorbic acid requirement of the guinea pig using growth and tissue ascorbic acid concentrations as criteria. J. Nutr., 64, 503-511. – reference: 3) Zannoni, V. G., Flynn, E. J., and Lynch, M. (1972): Ascorbic acid and drug metabolism. Biochem. Pharmacol., 21, 1377-1392. – reference: 9) Arakawa, N., Suzuki, E., Kurata, T., Otsuka, M., and Inagaki, C. (1986): Effect of erythorbic acid administration on ascorbic acid content in guinea pig tissues. J. Nutr. Sci. Vitaminol., 32, 171-181. – reference: 16) Desai, I. D. (1969): Regulation of lysosomal enzymes. I. Adaptive changes in enzyme activities during starvation and refeeding. Can. J. Biochem., 47, 785-790. – reference: 5) Turnbull, J. D., and Omaye, S. T. (1980): Synthesis on cytochrome P-450 hem in ascorbic acid-deficient guinea pigs. Biochem. Pharmacol., 29, 1255-1260. – reference: 1) Hornig, D. (1982): Impact of marginal vitamin C deficiency. J. Jap. Soc. Clin. Nutr., 3, 127-141. – reference: 8) Hoehn, S. K., and Kanfer, J. N. (1978): L-Ascorbic acid and lysosomal acid hydrolase activities of guinea pig liver and brain. Can. J. Biochem., 56, 352-356. – reference: 11) Chatterjee, G. C. (1967): Ascorbic acid requirements of animals, in The Vitamins, Vol. 1, ed. by Sebrell, W. H., Jr., and Harris, R. B., Academic Press, New York, pp. 495-500. – reference: 4) Zannoni, V. G., and Sato, P. H. (1975): Effects of ascorbic acid on microsomal drug metabolism. Ann. N. Y. Acad. Sci., 258, 119-131. – reference: 13) Boyle, P. E., Bessey, O. A., and Howe, P. R. (1940): Rate of dentin formation in incisor teeth of guinea pigs on normal and on ascorbic acid-deficient diets. A. M. A. Arch. Pathol., 30, 90-107. – reference: 17) Bessey, O. A., Lowry, O. H., and Brock, M. J. (1946): A method for the rapid determination of alkaline phosphatase with five cubic millimeters of serum. J. Biol. Chem., 164, 321-329. |
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| SubjectTerms | ACID PHOSPHATASE Acid Phosphatase - metabolism ACIDE ASCORBIQUE ACIDO ASCORBICO ALKALINE PHOSPHATASE Alkaline Phosphatase - metabolism aniline hydrox-ylase Aniline Hydroxylase - metabolism Animals ASCORBIC ACID Ascorbic Acid - administration & dosage Ascorbic Acid - pharmacology Ascorbic Acid Deficiency - enzymology CITOCROMO P 450 COBAYA COBAYE CYTOCHROME P 450 Cytochrome P-450 Enzyme System - metabolism erythorbic acid FOIE FOSFATASA ACIDA FOSFATASA ALCALINA guinea pig GUINEA PIGS HIGADO LIVER Liver - enzymology Male PHOSPHATASE ACIDE PHOSPHATASE ALCALINE serum alkaline phosphatase |
| Title | Effect of erythorbic acid administration on activities of drug metabolic enzyme and phosphatases in guinea pigs administered an adequate amount of ascorbic acid |
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