Gut-Busters: IL-17 Ain’t Afraid of No IL-23

• Published in: Immunity (Cambridge, Mass.) Vol. 43; no. 4; pp. 620 - 622
• Main Authors: Whibley, Natasha, Gaffen, Sarah L.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 20.10.2015; Elsevier Limited
• Subjects: Animals; Chemokines; Colitis - immunology; Colitis - physiopathology; Cytokines; Female; Gene expression; Humans; Immunoglobulins; Inflammation; Inflammatory bowel disease; Interleukin-17 - physiology; Interleukin-23 - physiology; Intestinal Mucosa - physiopathology; Localization; Lymphocytes; Permeability; Receptors, Interleukin-17 - physiology; Rodents

Interleukin-23 (IL-23) is considered a critical regulator of IL-17 in lymphocytes. Whereas antibodies targeting IL-23 ameliorate colitis, IL-17 neutralization exacerbates disease. In this issue, Cua and colleagues and Maxwell and colleagues show that IL-17 maintains intestinal barrier integrity, hel...