Gut-Busters: IL-17 Ain’t Afraid of No IL-23

Interleukin-23 (IL-23) is considered a critical regulator of IL-17 in lymphocytes. Whereas antibodies targeting IL-23 ameliorate colitis, IL-17 neutralization exacerbates disease. In this issue, Cua and colleagues and Maxwell and colleagues show that IL-17 maintains intestinal barrier integrity, hel...

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Bibliographic Details
Published inImmunity (Cambridge, Mass.) Vol. 43; no. 4; pp. 620 - 622
Main Authors Whibley, Natasha, Gaffen, Sarah L.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 20.10.2015
Elsevier Limited
Subjects
Animals
Chemokines
Colitis - immunology
Colitis - physiopathology
Cytokines
Female
Gene expression
Humans
Immunoglobulins
Inflammation
Inflammatory bowel disease
Interleukin-17 - physiology
Interleukin-23 - physiology
Intestinal Mucosa - physiopathology
Localization
Lymphocytes
Permeability
Receptors, Interleukin-17 - physiology
Rodents
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Summary:Interleukin-23 (IL-23) is considered a critical regulator of IL-17 in lymphocytes. Whereas antibodies targeting IL-23 ameliorate colitis, IL-17 neutralization exacerbates disease. In this issue, Cua and colleagues and Maxwell and colleagues show that IL-17 maintains intestinal barrier integrity, helping explain this dichotomy (Lee et al., 2015; Maxwell et al., 2015). Interleukin (IL-23) is considered a critical regulator of IL-17 in lymphocytes. Whereas antibodies targeting IL-23 ameliorate colitis, IL-17 neutralization exacerbates disease. Cua and colleagues and Maxwell and colleagues show that IL-17 maintains intestinal barrier integrity, helping explain this dichotomy (Lee et al., 2015; Maxwell et al., 2015).
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ISSN:1074-7613
1097-4180
DOI:10.1016/j.immuni.2015.10.001