Identification of Candidate Genes for Min Pig Villi Hair Traits by Genome-Wide Association of Copy Number Variation

• Published in: Veterinary sciences Vol. 10; no. 5; p. 307
• Main Authors: He, Xinmiao, Tian, Ming, Wang, Wentao, Feng, Yanzhong, Li, Zhongqiu, Wang, Jiahui, Song, Yan, Zhang, Jinfeng, Liu, Di
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 23.04.2023; MDPI
• Subjects: Analysis; Animal welfare; Breeding; Chromosome 1; Chromosomes; Cold; Cold resistance; Copy number; copy number variation; Disease resistance; G protein-coupled receptors; Genes; Genome-wide association studies; genome-wide association study; Genomes; Genomics; Genotype & phenotype; Hair; Hogs; Min pig; Phenotypes; Quality control; Quantitative genetics; Quantitative trait loci; Signal transduction; Swine; Variation; villi hair follicle; China; Beijing China; United States > US; Min pig; copy number variation; villi hair follicle; genome-wide association study
• ISSN: 2306-7381; 2306-7381
• DOI: 10.3390/vetsci10050307

The Min pig is a famous native pig breed in northeast China, which has the special genetic character of villi hair growth in cold seasons. At present, little research has focused on the genetic mechanism of villi hair growth in Min pigs. Copy number variations (CNVs) are a type of variant that may influence many traits. In this study, we first investigated the phenotype of Large White × Min pigs' F2 pig villi hair in detail and then performed a CNV-based genome-wide association study (GWAS) between CNVs and pig villi hair appearance. Finally, a total number of 15 significant CNVRs were found to be associated with Min pig villi hair. The most significant CNVR was located on chromosome 1. Nearest gene annotation analysis indicated that the pig villi hair traits may be associated with the biological process of the G-protein-coupled receptor signaling pathway. QTL overlapping analysis found that among the CNVRs, 14 CNVRs could be co-located with known QTLs. Some genes such as , , and may be candidate genes for pig villi traits and are worth further study. Our study may provide a basic reference for the selection and breeding of cold-resistant pigs and outdoor breeding.