DNA double-strand break repair in Caenorhabditis elegans

Faithful repair of DNA double-strand breaks (DSBs) is vital for animal development, as inappropriate repair can cause gross chromosomal alterations that result in cellular dysfunction, ultimately leading to cancer, or cell death. Correct processing of DSBs is not only essential for maintaining genom...

Full description

Saved in:
Bibliographic Details
Published inChromosoma Vol. 120; no. 1; pp. 1 - 21
Main Authors Lemmens, Bennie B. L. G, Tijsterman, Marcel
Format Journal Article
LanguageEnglish
Published Berlin/Heidelberg Berlin/Heidelberg : Springer-Verlag 01.02.2011
Springer-Verlag
Springer Nature B.V
Subjects
Animal Genetics and Genomics
Animals
Biochemistry
Biomedical and Life Sciences
Caenorhabditis elegans
Caenorhabditis elegans - genetics
Caenorhabditis elegans - metabolism
Cell Biology
Cell Cycle
Chromosome Deletion
Developmental Biology
DNA Breaks, Double-Stranded
DNA Repair
DNA, Single-Stranded - genetics
DNA, Single-Stranded - metabolism
Eukaryotic Microbiology
Evolution, Molecular
Human Genetics
Life Sciences
Nematoda
Review
Homologous Recombination
Synaptonemal Complex Component
RecQ Helicase
Meiotic DSBs
Synaptonemal Complex
Online AccessGet full text

Cover

More Information
Summary:Faithful repair of DNA double-strand breaks (DSBs) is vital for animal development, as inappropriate repair can cause gross chromosomal alterations that result in cellular dysfunction, ultimately leading to cancer, or cell death. Correct processing of DSBs is not only essential for maintaining genomic integrity, but is also required in developmental programs, such as gametogenesis, in which DSBs are deliberately generated. Accordingly, DSB repair deficiencies are associated with various developmental disorders including cancer predisposition and infertility. To avoid this threat, cells are equipped with an elaborate and evolutionarily well-conserved network of DSB repair pathways. In recent years, Caenorhabditis elegans has become a successful model system in which to study DSB repair, leading to important insights in this process during animal development. This review will discuss the major contributions and recent progress in the C. elegans field to elucidate the complex networks involved in DSB repair, the impact of which extends well beyond the nematode phylum.
Bibliography:http://dx.doi.org/10.1007/s00412-010-0296-3
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
Communicated by E. Nigg
ISSN:0009-5915
1432-0886
DOI:10.1007/s00412-010-0296-3